KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number

KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number

We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome n...

Full description

Bibliographic Details
Main Authors: Marjorie Fournier, László Tora
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:Molecular & Cellular Oncology
Subjects:
acetylation
cell cycle
centrosome
gcn5
genome stability
inhibition
kinase activity
pcaf
polo like kinase 4 (plk4)
proteomic analysis
Online Access:http://dx.doi.org/10.1080/23723556.2016.1270391
Description
Summary:We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability.
ISSN:2372-3556

Similar Items