KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome n...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-03-01
|
| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2016.1270391 |
| _version_ | 1797677179433123840 |
|---|---|
| author | Marjorie Fournier László Tora |
| author_facet | Marjorie Fournier László Tora |
| author_sort | Marjorie Fournier |
| collection | DOAJ |
| description | We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability. |
| first_indexed | 2024-03-11T22:41:19Z |
| format | Article |
| id | doaj.art-ec6964e0158c4803b495f44a677e95b3 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:19Z |
| publishDate | 2017-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-ec6964e0158c4803b495f44a677e95b32023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-03-014210.1080/23723556.2016.12703911270391KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome numberMarjorie Fournier0László Tora1Sir William Dunn School of Pathology, University of OxfordInstitut de Génétique et de Biologie Moléculaire et CellulaireWe have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability.http://dx.doi.org/10.1080/23723556.2016.1270391acetylationcell cyclecentrosomegcn5genome stabilityinhibitionkinase activitypcafpolo like kinase 4 (plk4)proteomic analysis |
| spellingShingle | Marjorie Fournier László Tora KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number Molecular & Cellular Oncology acetylation cell cycle centrosome gcn5 genome stability inhibition kinase activity pcaf polo like kinase 4 (plk4) proteomic analysis |
| title | KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number |
| title_full | KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number |
| title_fullStr | KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number |
| title_full_unstemmed | KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number |
| title_short | KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number |
| title_sort | kat2 mediated plk4 acetylation contributes to genomic stability by preserving centrosome number |
| topic | acetylation cell cycle centrosome gcn5 genome stability inhibition kinase activity pcaf polo like kinase 4 (plk4) proteomic analysis |
| url | http://dx.doi.org/10.1080/23723556.2016.1270391 |
| work_keys_str_mv | AT marjoriefournier kat2mediatedplk4acetylationcontributestogenomicstabilitybypreservingcentrosomenumber AT laszlotora kat2mediatedplk4acetylationcontributestogenomicstabilitybypreservingcentrosomenumber |