Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study
Objective: Chronic antigenic stimulation is frequently blamed in the pathogenesis of extranodal marginal zone lymphomas including splenic marginal zone lymphoma (SMZL). Chronic hepatitis C is frequently observed in SMZL patients in some geographical regions. However, these reports are largely from N...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2020-05-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-08870 |
| _version_ | 1828030128783884288 |
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| author | Müfide Okay Tuncay Aslan Evren Özdemir Ayşegül Üner Arzu Sağlam Elif Güngör Ayşe Uysal Nevin Alayvaz Aslan Esra Yıldızhan Abdullah Ağıt Mehmet Sinan Dal Serdal Korkmaz Sinem Namdaroğlu Serdar Sivgin Gülsüm Akgün Cağlıyan |
| author_facet | Müfide Okay Tuncay Aslan Evren Özdemir Ayşegül Üner Arzu Sağlam Elif Güngör Ayşe Uysal Nevin Alayvaz Aslan Esra Yıldızhan Abdullah Ağıt Mehmet Sinan Dal Serdal Korkmaz Sinem Namdaroğlu Serdar Sivgin Gülsüm Akgün Cağlıyan |
| author_sort | Müfide Okay |
| collection | DOAJ |
| description | Objective: Chronic antigenic stimulation is frequently blamed in the pathogenesis of extranodal marginal zone lymphomas including splenic marginal zone lymphoma (SMZL). Chronic hepatitis C is frequently observed in SMZL patients in some geographical regions. However, these reports are largely from North America and Europe, and data from other countries are insufficient. In this multicenter study we aimed to identify the clinical characteristics of SMZL patients in Turkey, including viral hepatitis status and treatment details. Materials and Methods: Data were gathered from participating centers from different regions of Turkey using IBM SPSS Statistics 23 for Windows. Hepatitis B virus surface antigen (HBsAg), anti-HBs antibody, anti-HB core antigen antibody (anti-HBcAg), HB viral load, anti-hepatitis C virus (HCV) antibody, HCV viral load results were analyzed. Results: One hundred and four patients were reported. Hepatitis C virus positivity was observed in only one patient. However, hepatitis B virus surface antigen (HBsAg) positivity was observed in 11.2% and HBsAg and/or anti-HB core antigen antibody (anti-HBcAg) positivities were seen in 34.2% of the patients. The median age was 60 years (range=35-87). Median follow-up duration was 21.2 months (range=00.2-212; 23.2 months for surviving patients). Median overall survival was not reached. Estimated 3-year and 10-year survival rates were 84.8% and 68.9%, respectively. Older age, no splenectomy during follow-up, platelet count of <90x103/µL, lower albumin, higher lactate dehydrogenase, higher β2-microglobulin, and HBsAg positivity were associated with increased risk of death. Only albumin remained significant in multivariable analysis. Conclusion: These results indicate that hepatitis B virus may be a possible risk factor for SMZL in our population. It may also be an indirect prognostic factor. |
| first_indexed | 2024-04-10T14:22:23Z |
| format | Article |
| id | doaj.art-ec6a87f1038f485a9ea4ce237c1fe371 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T14:22:23Z |
| publishDate | 2020-05-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-ec6a87f1038f485a9ea4ce237c1fe3712023-02-15T16:09:16ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632020-05-01372849010.4274/tjh.galenos.2019.2019.0177TJH-08870Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort StudyMüfide Okay0Tuncay Aslan1Evren Özdemir2Ayşegül Üner3Arzu Sağlam4Elif Güngör5Ayşe Uysal6Nevin Alayvaz Aslan7Esra Yıldızhan8Abdullah Ağıt9Mehmet Sinan Dal10Serdal Korkmaz11Sinem Namdaroğlu12Serdar Sivgin13Gülsüm Akgün Cağlıyan14Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, TurkeyMedicana International Ankara Hospital, Clinic of Medical Oncology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Pathology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Pathology, Ankara, TurkeyTrakya University Faculty of Medicine, Department of Internal Medicine, Edirne, TurkeyUniversity of Health Sciences, Trabzon Kanuni Training and Research Hospital, Division of Hematology, Trabzon, TurkeyOndokuz Mayıs University Faculty of Medicine, Department of Hematology, Samsun, TurkeyErciyes University Faculty of Medicine, Department of Hematology, Kayseri, TurkeyAnkara Numune Training and Research Hospital, Division of Hematology, Ankara, TurkeyUniversity of Health Sciences, Ankara Oncology Training and Research Hospital, Clinic of Hematology and BMT Unit, Ankara, TurkeyKayseri Training and Research Hospital, Division of Hematology, Kayseri, TurkeyUniversity of Health Sciences, İzmir, TurkeyAcıbadem Kayseri Hospital, Kayseri, TurkeyDenizli State Hospital, Division of Hematology, Denizli, TurkeyObjective: Chronic antigenic stimulation is frequently blamed in the pathogenesis of extranodal marginal zone lymphomas including splenic marginal zone lymphoma (SMZL). Chronic hepatitis C is frequently observed in SMZL patients in some geographical regions. However, these reports are largely from North America and Europe, and data from other countries are insufficient. In this multicenter study we aimed to identify the clinical characteristics of SMZL patients in Turkey, including viral hepatitis status and treatment details. Materials and Methods: Data were gathered from participating centers from different regions of Turkey using IBM SPSS Statistics 23 for Windows. Hepatitis B virus surface antigen (HBsAg), anti-HBs antibody, anti-HB core antigen antibody (anti-HBcAg), HB viral load, anti-hepatitis C virus (HCV) antibody, HCV viral load results were analyzed. Results: One hundred and four patients were reported. Hepatitis C virus positivity was observed in only one patient. However, hepatitis B virus surface antigen (HBsAg) positivity was observed in 11.2% and HBsAg and/or anti-HB core antigen antibody (anti-HBcAg) positivities were seen in 34.2% of the patients. The median age was 60 years (range=35-87). Median follow-up duration was 21.2 months (range=00.2-212; 23.2 months for surviving patients). Median overall survival was not reached. Estimated 3-year and 10-year survival rates were 84.8% and 68.9%, respectively. Older age, no splenectomy during follow-up, platelet count of <90x103/µL, lower albumin, higher lactate dehydrogenase, higher β2-microglobulin, and HBsAg positivity were associated with increased risk of death. Only albumin remained significant in multivariable analysis. Conclusion: These results indicate that hepatitis B virus may be a possible risk factor for SMZL in our population. It may also be an indirect prognostic factor.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-08870low-grade lymphomahepatitis b virushepatitis c virusrisk factors |
| spellingShingle | Müfide Okay Tuncay Aslan Evren Özdemir Ayşegül Üner Arzu Sağlam Elif Güngör Ayşe Uysal Nevin Alayvaz Aslan Esra Yıldızhan Abdullah Ağıt Mehmet Sinan Dal Serdal Korkmaz Sinem Namdaroğlu Serdar Sivgin Gülsüm Akgün Cağlıyan Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study Turkish Journal of Hematology low-grade lymphoma hepatitis b virus hepatitis c virus risk factors |
| title | Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study |
| title_full | Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study |
| title_fullStr | Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study |
| title_full_unstemmed | Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study |
| title_short | Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study |
| title_sort | splenic marginal zone lymphoma in turkey association with hepatitis b instead of hepatitis c virus as an etiologic and possible prognostic factor a multicenter cohort study |
| topic | low-grade lymphoma hepatitis b virus hepatitis c virus risk factors |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-08870 |
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