Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents
Sulphonylurea compounds have versatile activities such as antidiabetic, diuretic, herbicide, oncolytic, antimalarial, antifungal and anticancer. The present study describes the design, synthesis and in vivo testing of novel glycosylated aryl sulfonylurea compounds as antihyperglycaemic agents in str...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/11/19676 |
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| author | Ghadeer A. R. Y. Suaifan Mayadah B. Shehadeh Rula M. Darwish Hebah Al-Ijel Vincenzo Abbate |
| author_facet | Ghadeer A. R. Y. Suaifan Mayadah B. Shehadeh Rula M. Darwish Hebah Al-Ijel Vincenzo Abbate |
| author_sort | Ghadeer A. R. Y. Suaifan |
| collection | DOAJ |
| description | Sulphonylurea compounds have versatile activities such as antidiabetic, diuretic, herbicide, oncolytic, antimalarial, antifungal and anticancer. The present study describes the design, synthesis and in vivo testing of novel glycosylated aryl sulfonylurea compounds as antihyperglycaemic agents in streptozocine-induced diabetic mice. The rational for the introduction of the glucosamine moiety is to enhance selective drug uptake by pancreatic β-cells in order to decrease the cardiotoxic side effect commonly associated with sulfonylurea agents. 2-Deoxy-2-(4-chlorophenylsulfonylurea)-d-glucopyranose was found to be the most potent antihyperglycaemic agents among the synthesized compounds in diabetic mice. This investigation indicates the importance of this novel class as potential antihyperglycaemic agents. |
| first_indexed | 2024-12-10T15:14:49Z |
| format | Article |
| id | doaj.art-ec6c930c88db44fea5071458dc7ba064 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T15:14:49Z |
| publishDate | 2015-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ec6c930c88db44fea5071458dc7ba0642022-12-22T01:43:50ZengMDPI AGMolecules1420-30492015-11-012011200632007810.3390/molecules201119676molecules201119676Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic AgentsGhadeer A. R. Y. Suaifan0Mayadah B. Shehadeh1Rula M. Darwish2Hebah Al-Ijel3Vincenzo Abbate4Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, JordanInstitute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UKSulphonylurea compounds have versatile activities such as antidiabetic, diuretic, herbicide, oncolytic, antimalarial, antifungal and anticancer. The present study describes the design, synthesis and in vivo testing of novel glycosylated aryl sulfonylurea compounds as antihyperglycaemic agents in streptozocine-induced diabetic mice. The rational for the introduction of the glucosamine moiety is to enhance selective drug uptake by pancreatic β-cells in order to decrease the cardiotoxic side effect commonly associated with sulfonylurea agents. 2-Deoxy-2-(4-chlorophenylsulfonylurea)-d-glucopyranose was found to be the most potent antihyperglycaemic agents among the synthesized compounds in diabetic mice. This investigation indicates the importance of this novel class as potential antihyperglycaemic agents.http://www.mdpi.com/1420-3049/20/11/19676sulphonylureaantihyperglycemic agentsglucosaminestreptozocine |
| spellingShingle | Ghadeer A. R. Y. Suaifan Mayadah B. Shehadeh Rula M. Darwish Hebah Al-Ijel Vincenzo Abbate Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents Molecules sulphonylurea antihyperglycemic agents glucosamine streptozocine |
| title | Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents |
| title_full | Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents |
| title_fullStr | Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents |
| title_full_unstemmed | Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents |
| title_short | Design, Synthesis and in Vivo Evaluation of Novel Glycosylated Sulfonylureas as Antihyperglycemic Agents |
| title_sort | design synthesis and in vivo evaluation of novel glycosylated sulfonylureas as antihyperglycemic agents |
| topic | sulphonylurea antihyperglycemic agents glucosamine streptozocine |
| url | http://www.mdpi.com/1420-3049/20/11/19676 |
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