Is there a role for probiotics in the prevention of preterm birth?
Preterm Birth (PTB) continues to be a global health challenge. An over-production of inflammatory cytokines and chemokines, as well as an altered maternal vaginal microbiome has been implicated in the pathogenesis of inflammation/infection associated PTB. Lactobacillus represents the dominant speci...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00062/full |
| _version_ | 1811334968571330560 |
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| author | Siwen eYang Gregor eReid John RG Challis Sung O Kim Gregory B Gloor Alan Dixon Bocking Alan Dixon Bocking |
| author_facet | Siwen eYang Gregor eReid John RG Challis Sung O Kim Gregory B Gloor Alan Dixon Bocking Alan Dixon Bocking |
| author_sort | Siwen eYang |
| collection | DOAJ |
| description | Preterm Birth (PTB) continues to be a global health challenge. An over-production of inflammatory cytokines and chemokines, as well as an altered maternal vaginal microbiome has been implicated in the pathogenesis of inflammation/infection associated PTB. Lactobacillus represents the dominant species in the vagina of most healthy pregnant women. The depletion of Lactobacillus in women with bacterial vaginosis (BV) has been associated with an increased risk of PTB. It remains unknown at what point an aberrant vaginal microbiome composition specifically induces the cascade leading to PTB. The ability of oral or vaginal lactobacilli probiotics to reduce BV occurrence and/ or dampen inflammation is being considered as a means to prevent PTB. Certain anti-inflammatory properties of lactobacilli suggest potential mechanisms. To date, clinical studies have not been powered with sufficiently high rates of PTB, but overall there is merit in examining this promising area of clinical science. |
| first_indexed | 2024-04-13T17:16:10Z |
| format | Article |
| id | doaj.art-ec6c97458daa4b50b917c0d4e2038722 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T17:16:10Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec6c97458daa4b50b917c0d4e20387222022-12-22T02:38:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-02-01610.3389/fimmu.2015.00062125700Is there a role for probiotics in the prevention of preterm birth?Siwen eYang0Gregor eReid1John RG Challis2Sung O Kim3Gregory B Gloor4Alan Dixon Bocking5Alan Dixon Bocking6University of TorontoWestern UniversityUniversity of Western AustraliaWestern UniversityWestern UniversityUniversity of TorontoMount Sinai HospitalPreterm Birth (PTB) continues to be a global health challenge. An over-production of inflammatory cytokines and chemokines, as well as an altered maternal vaginal microbiome has been implicated in the pathogenesis of inflammation/infection associated PTB. Lactobacillus represents the dominant species in the vagina of most healthy pregnant women. The depletion of Lactobacillus in women with bacterial vaginosis (BV) has been associated with an increased risk of PTB. It remains unknown at what point an aberrant vaginal microbiome composition specifically induces the cascade leading to PTB. The ability of oral or vaginal lactobacilli probiotics to reduce BV occurrence and/ or dampen inflammation is being considered as a means to prevent PTB. Certain anti-inflammatory properties of lactobacilli suggest potential mechanisms. To date, clinical studies have not been powered with sufficiently high rates of PTB, but overall there is merit in examining this promising area of clinical science.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00062/fullCytokinesProbioticsPreterm Birthbacterial vaginosisvaginal microbiomeInfection and inflammation |
| spellingShingle | Siwen eYang Gregor eReid John RG Challis Sung O Kim Gregory B Gloor Alan Dixon Bocking Alan Dixon Bocking Is there a role for probiotics in the prevention of preterm birth? Frontiers in Immunology Cytokines Probiotics Preterm Birth bacterial vaginosis vaginal microbiome Infection and inflammation |
| title | Is there a role for probiotics in the prevention of preterm birth? |
| title_full | Is there a role for probiotics in the prevention of preterm birth? |
| title_fullStr | Is there a role for probiotics in the prevention of preterm birth? |
| title_full_unstemmed | Is there a role for probiotics in the prevention of preterm birth? |
| title_short | Is there a role for probiotics in the prevention of preterm birth? |
| title_sort | is there a role for probiotics in the prevention of preterm birth |
| topic | Cytokines Probiotics Preterm Birth bacterial vaginosis vaginal microbiome Infection and inflammation |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00062/full |
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