Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease
Abstract Adipocyte hypertrophy and expression of adipokines in subcutaneous adipose tissue (SAT) have been linked to steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis in morbidly obese (BMI ≥ 40 kg/m2) subjects. It is unknown if this is also true for subjects with NAFLD with lesser degrees...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-24482-1 |
| _version_ | 1811315317389918208 |
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| author | Magnus Holmer Hannes Hagström Ping Chen Olof Danielsson Myriam Aouadi Mikael Rydén Per Stål |
| author_facet | Magnus Holmer Hannes Hagström Ping Chen Olof Danielsson Myriam Aouadi Mikael Rydén Per Stål |
| author_sort | Magnus Holmer |
| collection | DOAJ |
| description | Abstract Adipocyte hypertrophy and expression of adipokines in subcutaneous adipose tissue (SAT) have been linked to steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis in morbidly obese (BMI ≥ 40 kg/m2) subjects. It is unknown if this is also true for subjects with NAFLD with lesser degrees of obesity (BMI < 35 kg/m2). Thirty-two subjects with biopsy-proven NAFLD and 15 non-diabetic controls matched for BMI underwent fine-needle biopsies of SAT. Adipocyte volume was calculated. RNA-sequencing of SAT was performed in a subset of 20 NAFLD patients. Adipocyte volume and gene expression levels were correlated to the presence of NASH or significant fibrosis. Subjects with NAFLD had larger adipocyte volume compared with controls, (1939 pL, 95% CI 1130–1662 vs. 854 pL, 95% CI 781–926, p < 0.001). There was no association between adipocyte volume and the presence of NASH. Gene expression of adipokines previously described to correlate with NASH in morbid obesity, was not associated with NASH or fibrosis. Our results suggest that persons with NAFLD have larger SAT adipocytes compared with controls and that adipocytes are involved in the pathophysiology of hepatic steatosis in NAFLD. However, adipocyte volume was not associated with NASH or fibrosis in NAFLD subjects with varying degrees of obesity. |
| first_indexed | 2024-04-13T11:28:07Z |
| format | Article |
| id | doaj.art-ec6e91cb84394d3cbf060230f277580a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T11:28:07Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ec6e91cb84394d3cbf060230f277580a2022-12-22T02:48:38ZengNature PortfolioScientific Reports2045-23222022-11-011211810.1038/s41598-022-24482-1Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver diseaseMagnus Holmer0Hannes Hagström1Ping Chen2Olof Danielsson3Myriam Aouadi4Mikael Rydén5Per Stål6Division of Liver and Pancreatic Diseases, Department of Upper GI, Huddinge C1-77, Karolinska University HospitalDivision of Liver and Pancreatic Diseases, Department of Upper GI, Huddinge C1-77, Karolinska University HospitalDepartment of Medicine, Huddinge, Center for Infectious Medicine (CIM), Karolinska Institutet, Karolinska University HospitalDivision of Pathology, Department of Laboratory Medicine, Huddinge, Karolinska Institutet, Karolinska University HospitalDepartment of Medicine, Huddinge, Center for Infectious Medicine (CIM), Karolinska Institutet, Karolinska University HospitalEndocrinology Unit, Department of Medicine, Huddinge, Karolinska Institutet, Karolinska University HospitalDivision of Liver and Pancreatic Diseases, Department of Upper GI, Huddinge C1-77, Karolinska University HospitalAbstract Adipocyte hypertrophy and expression of adipokines in subcutaneous adipose tissue (SAT) have been linked to steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis in morbidly obese (BMI ≥ 40 kg/m2) subjects. It is unknown if this is also true for subjects with NAFLD with lesser degrees of obesity (BMI < 35 kg/m2). Thirty-two subjects with biopsy-proven NAFLD and 15 non-diabetic controls matched for BMI underwent fine-needle biopsies of SAT. Adipocyte volume was calculated. RNA-sequencing of SAT was performed in a subset of 20 NAFLD patients. Adipocyte volume and gene expression levels were correlated to the presence of NASH or significant fibrosis. Subjects with NAFLD had larger adipocyte volume compared with controls, (1939 pL, 95% CI 1130–1662 vs. 854 pL, 95% CI 781–926, p < 0.001). There was no association between adipocyte volume and the presence of NASH. Gene expression of adipokines previously described to correlate with NASH in morbid obesity, was not associated with NASH or fibrosis. Our results suggest that persons with NAFLD have larger SAT adipocytes compared with controls and that adipocytes are involved in the pathophysiology of hepatic steatosis in NAFLD. However, adipocyte volume was not associated with NASH or fibrosis in NAFLD subjects with varying degrees of obesity.https://doi.org/10.1038/s41598-022-24482-1 |
| spellingShingle | Magnus Holmer Hannes Hagström Ping Chen Olof Danielsson Myriam Aouadi Mikael Rydén Per Stål Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease Scientific Reports |
| title | Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease |
| title_full | Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease |
| title_fullStr | Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease |
| title_full_unstemmed | Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease |
| title_short | Associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease |
| title_sort | associations between subcutaneous adipocyte hypertrophy and nonalcoholic fatty liver disease |
| url | https://doi.org/10.1038/s41598-022-24482-1 |
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