Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas

Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas

Gliomas represent 70% of all central system nervous tumors and are classified according to the degree of malignancy as low- or high-grade. The permanent activation of the EGFR/PI3K/AKT pathway by various genetic or post-translational alterations of EGFR, PI3KCA, and PTEN has been associated with inc...

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Bibliographic Details
Main Authors: Alveiro Erira, Fernando Velandia, José Penagos, Camilo Zubieta, Gonzalo Arboleda
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Brain Sciences
Subjects:
cancer
gliomas
pathway
proliferation
apoptosis
Online Access:https://www.mdpi.com/2076-3425/11/12/1655

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