Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design

Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design

A novel, stability indicating, reverse phase high-performance liquid chromatography (RP-HPLC) method was developed to determine the S-isomer of linagliptin (LGP) in linagliptin and metformin hydrochloride (MET HCl) tablets (LGP–MET HCl) by implementing design of experiment (DoE), i.e., two-level, fu...

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Bibliographic Details
Main Authors: Sushant B. Jadhav, Rahul M. Mane, Kalyanraman L. Narayanan, Popatrao N. Bhosale
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Scientia Pharmaceutica
Subjects:
S-isomer
enantiomer
design of experiments (DoE)
development
linagliptin and metformin hydrochloride
Online Access:http://www.mdpi.com/2218-0532/84/4/671

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