Involvement of l-lactate in hippocampal dysfunction of type I diabetes
Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-09-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319357068 |
| _version_ | 1818281808550166528 |
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| author | Riho Kobayashi Junya Maruoka Hiroaki Norimoto Yuji Ikegaya Kazuhiko Kume Masahiro Ohsawa |
| author_facet | Riho Kobayashi Junya Maruoka Hiroaki Norimoto Yuji Ikegaya Kazuhiko Kume Masahiro Ohsawa |
| author_sort | Riho Kobayashi |
| collection | DOAJ |
| description | Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of l-lactate, a major neural energy source. The cognitive impairment in diabetic mice was alleviated by intracerebroventricular l-lactate treatment. Our results suggested that l-lactate is important for hippocampal dysfunction in diabetes. Keywords: Sharp wave ripples (SW-Rs), Diabetes mellitus, Cognitive impairment |
| first_indexed | 2024-12-13T00:11:00Z |
| format | Article |
| id | doaj.art-ec70b630a91248d1b2e6803311972a04 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-13T00:11:00Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-ec70b630a91248d1b2e6803311972a042022-12-22T00:05:58ZengElsevierJournal of Pharmacological Sciences1347-86132019-09-0114117982Involvement of l-lactate in hippocampal dysfunction of type I diabetesRiho Kobayashi0Junya Maruoka1Hiroaki Norimoto2Yuji Ikegaya3Kazuhiko Kume4Masahiro Ohsawa5Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, JapanDepartment of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, JapanLaboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, JapanLaboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, JapanDepartment of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, JapanDepartment of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; Corresponding author. Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan. Fax: +81 532 836 3676.Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of l-lactate, a major neural energy source. The cognitive impairment in diabetic mice was alleviated by intracerebroventricular l-lactate treatment. Our results suggested that l-lactate is important for hippocampal dysfunction in diabetes. Keywords: Sharp wave ripples (SW-Rs), Diabetes mellitus, Cognitive impairmenthttp://www.sciencedirect.com/science/article/pii/S1347861319357068 |
| spellingShingle | Riho Kobayashi Junya Maruoka Hiroaki Norimoto Yuji Ikegaya Kazuhiko Kume Masahiro Ohsawa Involvement of l-lactate in hippocampal dysfunction of type I diabetes Journal of Pharmacological Sciences |
| title | Involvement of l-lactate in hippocampal dysfunction of type I diabetes |
| title_full | Involvement of l-lactate in hippocampal dysfunction of type I diabetes |
| title_fullStr | Involvement of l-lactate in hippocampal dysfunction of type I diabetes |
| title_full_unstemmed | Involvement of l-lactate in hippocampal dysfunction of type I diabetes |
| title_short | Involvement of l-lactate in hippocampal dysfunction of type I diabetes |
| title_sort | involvement of l lactate in hippocampal dysfunction of type i diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319357068 |
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