SCN5A Variants: Association With Cardiac Disorders

SCN5A Variants: Association With Cardiac Disorders

The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1.5. This channel predominates inward sodium current (INa) and plays a critical role in regulation of cardiac electrophysiological function. Since 1995, SCN5A variants have been found to be causatively associated with Bru...

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Bibliographic Details
Main Authors:	Wenjia Li, Lei Yin, Cheng Shen, Kai Hu, Junbo Ge, Aijun Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-10-01
Series:	Frontiers in Physiology
Subjects:	SCN5A Nav1.5 cardiac disorders cardiac sodium channelopathy therapeutic potential
Online Access:	https://www.frontiersin.org/article/10.3389/fphys.2018.01372/full

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