Genomic Insults and their Redressal in the Eutopic Endometrium of Women with Endometriosis
Endometrium, a highly dynamic tissue, is known for its remarkable ability to regenerate, differentiate, and degenerate in a non-conception cycle and transform into a specialized tissue to nurture and protect the embryo in a conception cycle. This plasticity of the endometrium endows the uterus to ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Reproductive Medicine |
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| Online Access: | https://www.mdpi.com/2673-3897/4/2/9 |
| _version_ | 1797592816282501120 |
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| author | Itti Munshi Geetanjali Sachdeva |
| author_facet | Itti Munshi Geetanjali Sachdeva |
| author_sort | Itti Munshi |
| collection | DOAJ |
| description | Endometrium, a highly dynamic tissue, is known for its remarkable ability to regenerate, differentiate, and degenerate in a non-conception cycle and transform into a specialized tissue to nurture and protect the embryo in a conception cycle. This plasticity of the endometrium endows the uterus to execute its major function, i.e., embryo implantation. However, this boon becomes a bane, when endometrium- or endometrium-like cells adhere, grow, and invade extrauterine sites, leading to endometriosis. Endometrial deposits at the extrauterine site lead to severe pelvic pain, painful menstruation, and infertility in endometriosis. Although benign, endometriotic lesions share several traits with cancerous cells, excessive proliferation, adhesion, invasion, and angiogenesis make endometriotic lesions analogous to cancer cells in certain aspects. There exists evidence to support that, akin to the cancer cell, endometriotic lesions harbor somatic mutations. These lesions are known to experience higher proliferative stress, oxidative stress, and inflammation, which may contribute to somatic mutations. However, it would be of more interest to establish whether in the eutopic endometriosis also, the mutational burden is higher or whether the DNA Damage Response (DDR) is compromised in the eutopic endometrium, in endometriosis. Such investigations may provide more insights into the pathobiology of endometriosis and may also unravel cellular events associated with the origin of the disease. This review compiles inferences from the studies conducted to assess DNA damage and DDR in endometriosis. |
| first_indexed | 2024-03-11T01:58:29Z |
| format | Article |
| id | doaj.art-ec7442941f0e455d870b27fe7caf3529 |
| institution | Directory Open Access Journal |
| issn | 2673-3897 |
| language | English |
| last_indexed | 2024-03-11T01:58:29Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reproductive Medicine |
| spelling | doaj.art-ec7442941f0e455d870b27fe7caf35292023-11-18T12:28:10ZengMDPI AGReproductive Medicine2673-38972023-04-0142748810.3390/reprodmed4020009Genomic Insults and their Redressal in the Eutopic Endometrium of Women with EndometriosisItti Munshi0Geetanjali Sachdeva1Cell Physiology and Pathology Laboratory, Indian Council of Medical Research-National Institute for Research in Reproductive and Child Health (ICMR-NIRRCH), Mumbai 400012, IndiaCell Physiology and Pathology Laboratory, Indian Council of Medical Research-National Institute for Research in Reproductive and Child Health (ICMR-NIRRCH), Mumbai 400012, IndiaEndometrium, a highly dynamic tissue, is known for its remarkable ability to regenerate, differentiate, and degenerate in a non-conception cycle and transform into a specialized tissue to nurture and protect the embryo in a conception cycle. This plasticity of the endometrium endows the uterus to execute its major function, i.e., embryo implantation. However, this boon becomes a bane, when endometrium- or endometrium-like cells adhere, grow, and invade extrauterine sites, leading to endometriosis. Endometrial deposits at the extrauterine site lead to severe pelvic pain, painful menstruation, and infertility in endometriosis. Although benign, endometriotic lesions share several traits with cancerous cells, excessive proliferation, adhesion, invasion, and angiogenesis make endometriotic lesions analogous to cancer cells in certain aspects. There exists evidence to support that, akin to the cancer cell, endometriotic lesions harbor somatic mutations. These lesions are known to experience higher proliferative stress, oxidative stress, and inflammation, which may contribute to somatic mutations. However, it would be of more interest to establish whether in the eutopic endometriosis also, the mutational burden is higher or whether the DNA Damage Response (DDR) is compromised in the eutopic endometrium, in endometriosis. Such investigations may provide more insights into the pathobiology of endometriosis and may also unravel cellular events associated with the origin of the disease. This review compiles inferences from the studies conducted to assess DNA damage and DDR in endometriosis.https://www.mdpi.com/2673-3897/4/2/9endometriosisDNA damage responseendometriummutations |
| spellingShingle | Itti Munshi Geetanjali Sachdeva Genomic Insults and their Redressal in the Eutopic Endometrium of Women with Endometriosis Reproductive Medicine endometriosis DNA damage response endometrium mutations |
| title | Genomic Insults and their Redressal in the Eutopic Endometrium of Women with Endometriosis |
| title_full | Genomic Insults and their Redressal in the Eutopic Endometrium of Women with Endometriosis |
| title_fullStr | Genomic Insults and their Redressal in the Eutopic Endometrium of Women with Endometriosis |
| title_full_unstemmed | Genomic Insults and their Redressal in the Eutopic Endometrium of Women with Endometriosis |
| title_short | Genomic Insults and their Redressal in the Eutopic Endometrium of Women with Endometriosis |
| title_sort | genomic insults and their redressal in the eutopic endometrium of women with endometriosis |
| topic | endometriosis DNA damage response endometrium mutations |
| url | https://www.mdpi.com/2673-3897/4/2/9 |
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