Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study
Background: Understanding the mental health consequences of child maltreatment at different life stages is important in accurately quantifying the burden of maltreatment. This study investigated the association between child maltreatment and incident mental disorders in middle and older age as well...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | The Lancet Regional Health. Europe |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266677622100209X |
| _version_ | 1819195536084828160 |
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| author | John M Macpherson Stuart R Gray Patrick Ip Marianne McCallum Peter Hanlon Paul Welsh Ko Ling Chan Frances S Mair Carlos Celis-Morales Helen Minnis Jill P Pell Frederick K Ho |
| author_facet | John M Macpherson Stuart R Gray Patrick Ip Marianne McCallum Peter Hanlon Paul Welsh Ko Ling Chan Frances S Mair Carlos Celis-Morales Helen Minnis Jill P Pell Frederick K Ho |
| author_sort | John M Macpherson |
| collection | DOAJ |
| description | Background: Understanding the mental health consequences of child maltreatment at different life stages is important in accurately quantifying the burden of maltreatment. This study investigated the association between child maltreatment and incident mental disorders in middle and older age as well as the potential mediators and moderators. Methods: This is a retrospective cohort study of 56,082 participants from UK Biobank. Child maltreatment was recalled using the Childhood Trauma Screener. Incident mental disorders, including depressive, anxiety and affective disorders, behavioural syndromes, post-traumatic stress disorder (PTSD), schizophrenia, substance abuse, and dementia, after baseline assessment were ascertained through linkage to primary care records. Findings: There was a dose-response relationship between child maltreatment and mental disorder. Those who experienced three or more maltreatment types had the highest risk of all mental disorders (HR 1.85, 95% CI: 1.67-2.06) followed by those who experienced two (HR 1.48, 95% CI: 1.35-1.63) and then one (HR 1.26, 95% CI: 1.19-2.35). Child maltreatment was most strongly associated with PTSD (HR 1.59, 95% CI: 1.20-2.10 P=0.001). The excess risk was largely unexplained by the included mediators. The association between child maltreatment and all mental disorders were stronger among participants who binge drank (Pinteraction=0.003) or had few social visits (Pinteraction=0.003). Interpretation: The mental health consequence of child maltreatment could last decades, even among those who had no recorded mental disorders in early adulthood. In the absence of strong mediators, prevention of child maltreatment remains the priority. Funding: Wellcome Trust Institutional Strategic Support Fund |
| first_indexed | 2024-12-23T02:14:19Z |
| format | Article |
| id | doaj.art-ec75d98857f9418aaa34406b15732e1f |
| institution | Directory Open Access Journal |
| issn | 2666-7762 |
| language | English |
| last_indexed | 2024-12-23T02:14:19Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Europe |
| spelling | doaj.art-ec75d98857f9418aaa34406b15732e1f2022-12-21T18:03:42ZengElsevierThe Lancet Regional Health. Europe2666-77622021-12-0111100224Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort studyJohn M Macpherson0Stuart R Gray1Patrick Ip2Marianne McCallum3Peter Hanlon4Paul Welsh5Ko Ling Chan6Frances S Mair7Carlos Celis-Morales8Helen Minnis9Jill P Pell10Frederick K Ho11Institute of Health and Wellbeing, University of Glasgow, United KingdomInstitute of Cardiovascular & Medical Sciences, University of Glasgow, United KingdomDepartment of Paediatrics and Adolescent Medicine, University of Hong KongInstitute of Health and Wellbeing, University of Glasgow, United KingdomInstitute of Health and Wellbeing, University of Glasgow, United KingdomInstitute of Cardiovascular & Medical Sciences, University of Glasgow, United KingdomDepartment of Applied Social Sciences, Hong Kong Polytechnic UniversityInstitute of Health and Wellbeing, University of Glasgow, United KingdomInstitute of Health and Wellbeing, University of Glasgow, United Kingdom; Institute of Cardiovascular & Medical Sciences, University of Glasgow, United KingdomInstitute of Health and Wellbeing, University of Glasgow, United KingdomInstitute of Health and Wellbeing, University of Glasgow, United KingdomInstitute of Health and Wellbeing, University of Glasgow, United Kingdom; Corresponding author: Frederick Ho, Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, United KingdomBackground: Understanding the mental health consequences of child maltreatment at different life stages is important in accurately quantifying the burden of maltreatment. This study investigated the association between child maltreatment and incident mental disorders in middle and older age as well as the potential mediators and moderators. Methods: This is a retrospective cohort study of 56,082 participants from UK Biobank. Child maltreatment was recalled using the Childhood Trauma Screener. Incident mental disorders, including depressive, anxiety and affective disorders, behavioural syndromes, post-traumatic stress disorder (PTSD), schizophrenia, substance abuse, and dementia, after baseline assessment were ascertained through linkage to primary care records. Findings: There was a dose-response relationship between child maltreatment and mental disorder. Those who experienced three or more maltreatment types had the highest risk of all mental disorders (HR 1.85, 95% CI: 1.67-2.06) followed by those who experienced two (HR 1.48, 95% CI: 1.35-1.63) and then one (HR 1.26, 95% CI: 1.19-2.35). Child maltreatment was most strongly associated with PTSD (HR 1.59, 95% CI: 1.20-2.10 P=0.001). The excess risk was largely unexplained by the included mediators. The association between child maltreatment and all mental disorders were stronger among participants who binge drank (Pinteraction=0.003) or had few social visits (Pinteraction=0.003). Interpretation: The mental health consequence of child maltreatment could last decades, even among those who had no recorded mental disorders in early adulthood. In the absence of strong mediators, prevention of child maltreatment remains the priority. Funding: Wellcome Trust Institutional Strategic Support Fundhttp://www.sciencedirect.com/science/article/pii/S266677622100209XChild AbuseMental HealthCohort Studies |
| spellingShingle | John M Macpherson Stuart R Gray Patrick Ip Marianne McCallum Peter Hanlon Paul Welsh Ko Ling Chan Frances S Mair Carlos Celis-Morales Helen Minnis Jill P Pell Frederick K Ho Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study The Lancet Regional Health. Europe Child Abuse Mental Health Cohort Studies |
| title | Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study |
| title_full | Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study |
| title_fullStr | Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study |
| title_full_unstemmed | Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study |
| title_short | Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study |
| title_sort | child maltreatment and incident mental disorders in middle and older ages a retrospective uk biobank cohort study |
| topic | Child Abuse Mental Health Cohort Studies |
| url | http://www.sciencedirect.com/science/article/pii/S266677622100209X |
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