Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy
Mesial temporal lobe epilepsy is the most common type of focal epilepsy, imposing a significant burden on the health care system worldwide. Approximately one-third of patients with this disease who do not adequately respond to pharmacotherapy are considered drug-resistant subjects. Despite having so...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1217702/full |
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| author | Elena A. Filimonova Elena A. Filimonova Anton A. Pashkov Anton A. Pashkov Galina I. Moysak Galina I. Moysak Anastasia Y. Tropynina Anastasia Y. Tropynina Svetlana Y. Zhanaeva Anna A. Shvaikovskaya Anna A. Akopyan Konstantin V. Danilenko Lyubomir I. Aftanas Lyubomir I. Aftanas Maria A. Tikhonova Jamil A. Rzaev Jamil A. Rzaev Jamil A. Rzaev |
| author_facet | Elena A. Filimonova Elena A. Filimonova Anton A. Pashkov Anton A. Pashkov Galina I. Moysak Galina I. Moysak Anastasia Y. Tropynina Anastasia Y. Tropynina Svetlana Y. Zhanaeva Anna A. Shvaikovskaya Anna A. Akopyan Konstantin V. Danilenko Lyubomir I. Aftanas Lyubomir I. Aftanas Maria A. Tikhonova Jamil A. Rzaev Jamil A. Rzaev Jamil A. Rzaev |
| author_sort | Elena A. Filimonova |
| collection | DOAJ |
| description | Mesial temporal lobe epilepsy is the most common type of focal epilepsy, imposing a significant burden on the health care system worldwide. Approximately one-third of patients with this disease who do not adequately respond to pharmacotherapy are considered drug-resistant subjects. Despite having some clues of how such epileptic activity and resistance to therapy emerge, coming mainly from preclinical models, we still witness a scarcity of human data. To narrow this gap, in this study, we aimed to estimate the relationship between hippocampal and serum levels of brain-derived neurotrophic factor (BDNF), one of the main and most widely studied neurotrophins, and hippocampal subfield volumes in patients with drug-resistant mesial temporal epilepsy undergoing neurosurgical treatment. We found that hippocampal (but not serum) BDNF levels were negatively correlated with the contralateral volumes of the CA1 and CA4 subfields, presubiculum, subiculum, dentate gyrus, and molecular layer of the hippocampus. Taken together, these findings are generally in accordance with existing data, arguing for a proepileptic nature of BDNF effects in the hippocampus and related brain structures. |
| first_indexed | 2024-03-12T23:04:12Z |
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| id | doaj.art-ec768bc59f5144f89d8be5a97ff05889 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T23:04:12Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-ec768bc59f5144f89d8be5a97ff058892023-07-19T06:15:54ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-07-011710.3389/fnins.2023.12177021217702Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsyElena A. Filimonova0Elena A. Filimonova1Anton A. Pashkov2Anton A. Pashkov3Galina I. Moysak4Galina I. Moysak5Anastasia Y. Tropynina6Anastasia Y. Tropynina7Svetlana Y. Zhanaeva8Anna A. Shvaikovskaya9Anna A. Akopyan10Konstantin V. Danilenko11Lyubomir I. Aftanas12Lyubomir I. Aftanas13Maria A. Tikhonova14Jamil A. Rzaev15Jamil A. Rzaev16Jamil A. Rzaev17FSBI "Federal Center of Neurosurgery", Novosibirsk, RussiaDepartment of Neurosurgery, Novosibirsk State Medical University, Novosibirsk, RussiaFSBI "Federal Center of Neurosurgery", Novosibirsk, RussiaBiomedical School, South Ural State University, Chelyabinsk, RussiaFSBI "Federal Center of Neurosurgery", Novosibirsk, RussiaDepartment of Neuroscience, Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, RussiaDepartment of Neuroscience, Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, RussiaScientific Research Institute of Neurosciences and Medicine, Novosibirsk, RussiaScientific Research Institute of Neurosciences and Medicine, Novosibirsk, RussiaScientific Research Institute of Neurosciences and Medicine, Novosibirsk, RussiaScientific Research Institute of Neurosciences and Medicine, Novosibirsk, RussiaScientific Research Institute of Neurosciences and Medicine, Novosibirsk, RussiaDepartment of Neuroscience, Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, RussiaScientific Research Institute of Neurosciences and Medicine, Novosibirsk, RussiaScientific Research Institute of Neurosciences and Medicine, Novosibirsk, RussiaFSBI "Federal Center of Neurosurgery", Novosibirsk, RussiaDepartment of Neurosurgery, Novosibirsk State Medical University, Novosibirsk, RussiaDepartment of Neuroscience, Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, RussiaMesial temporal lobe epilepsy is the most common type of focal epilepsy, imposing a significant burden on the health care system worldwide. Approximately one-third of patients with this disease who do not adequately respond to pharmacotherapy are considered drug-resistant subjects. Despite having some clues of how such epileptic activity and resistance to therapy emerge, coming mainly from preclinical models, we still witness a scarcity of human data. To narrow this gap, in this study, we aimed to estimate the relationship between hippocampal and serum levels of brain-derived neurotrophic factor (BDNF), one of the main and most widely studied neurotrophins, and hippocampal subfield volumes in patients with drug-resistant mesial temporal epilepsy undergoing neurosurgical treatment. We found that hippocampal (but not serum) BDNF levels were negatively correlated with the contralateral volumes of the CA1 and CA4 subfields, presubiculum, subiculum, dentate gyrus, and molecular layer of the hippocampus. Taken together, these findings are generally in accordance with existing data, arguing for a proepileptic nature of BDNF effects in the hippocampus and related brain structures.https://www.frontiersin.org/articles/10.3389/fnins.2023.1217702/fullmesial temporal lobe epilepsydrug-resistant epilepsyBDNFMR morphometryFreeSurferhippocampus |
| spellingShingle | Elena A. Filimonova Elena A. Filimonova Anton A. Pashkov Anton A. Pashkov Galina I. Moysak Galina I. Moysak Anastasia Y. Tropynina Anastasia Y. Tropynina Svetlana Y. Zhanaeva Anna A. Shvaikovskaya Anna A. Akopyan Konstantin V. Danilenko Lyubomir I. Aftanas Lyubomir I. Aftanas Maria A. Tikhonova Jamil A. Rzaev Jamil A. Rzaev Jamil A. Rzaev Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy Frontiers in Neuroscience mesial temporal lobe epilepsy drug-resistant epilepsy BDNF MR morphometry FreeSurfer hippocampus |
| title | Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy |
| title_full | Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy |
| title_fullStr | Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy |
| title_full_unstemmed | Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy |
| title_short | Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy |
| title_sort | brain but not serum bdnf levels are associated with structural alterations in the hippocampal regions in patients with drug resistant mesial temporal lobe epilepsy |
| topic | mesial temporal lobe epilepsy drug-resistant epilepsy BDNF MR morphometry FreeSurfer hippocampus |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1217702/full |
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