Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of Thinking
Mosquito-borne malaria kills 429,000 people each year with the problem being acute in sub-Saharan Africa. The successes gained with long-lasting pyrethroid-treated bednets are now in jeopardy because of wide-spread, pyrethroid resistance in mosquitoes. Using crowd modeling theory normalized for stan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Insects |
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| Online Access: | https://www.mdpi.com/2075-4450/11/11/732 |
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| author | Chouaibou S. Mouhamadou Kun Luan Behi K. Fodjo Andre J. West Marian G. McCord Charles S. Apperson R. Michael Roe |
| author_facet | Chouaibou S. Mouhamadou Kun Luan Behi K. Fodjo Andre J. West Marian G. McCord Charles S. Apperson R. Michael Roe |
| author_sort | Chouaibou S. Mouhamadou |
| collection | DOAJ |
| description | Mosquito-borne malaria kills 429,000 people each year with the problem being acute in sub-Saharan Africa. The successes gained with long-lasting pyrethroid-treated bednets are now in jeopardy because of wide-spread, pyrethroid resistance in mosquitoes. Using crowd modeling theory normalized for standard bednet architecture, we were able to design an attract–trap–kill technology for mosquitoes that does not require insecticides. Using three-dimensional polyester knitting and heat fixation, trap funnels were developed with high capture efficacy with no egression under worst-case laboratory conditions. Field testing in Africa in WHO huts with Gen1-3 T (trap)-Nets validated our model, and as predicted, Gen3 had the highest efficacy with a 4.3-fold greater trap–kill rate with no deterrence or repellency compared to Permanet 2.0, the most common bednet in Africa. A T-Net population model was developed based on field data to predict community-level mosquito control compared to a pyrethroid bednet. This model showed the Gen3 non-insecticidal T-Net under field conditions in Africa against pyrethroid resistant mosquitoes was 12.7-fold more efficacious than single chemical, pyrethroid-treated nets. |
| first_indexed | 2024-03-10T15:20:14Z |
| format | Article |
| id | doaj.art-ec77b8067a7140c282268e83ff7de102 |
| institution | Directory Open Access Journal |
| issn | 2075-4450 |
| language | English |
| last_indexed | 2024-03-10T15:20:14Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Insects |
| spelling | doaj.art-ec77b8067a7140c282268e83ff7de1022023-11-20T18:37:29ZengMDPI AGInsects2075-44502020-10-01111173210.3390/insects11110732Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of ThinkingChouaibou S. Mouhamadou0Kun Luan1Behi K. Fodjo2Andre J. West3Marian G. McCord4Charles S. Apperson5R. Michael Roe6Centre Suisse de Recherches Scientifiques en Côte d’Ivoire (CSRS), 01BP, Abidjan 1301, Cote d’IvoireCollege of Natural Resources, Campus Box 8001, 2820 Faucette Drive, North Carolina State University, Raleigh, NC 27695, USACentre Suisse de Recherches Scientifiques en Côte d’Ivoire (CSRS), 01BP, Abidjan 1301, Cote d’IvoireDepartment of Textile and Apparel, Technology and Management, North Carolina State University, Raleigh, NC 27695, USACollege of Natural Resources, Campus Box 8001, 2820 Faucette Drive, North Carolina State University, Raleigh, NC 27695, USADepartment of Entomology and Plant Pathology, Campus Box 7647, 3230 Ligon Street, North Carolina State University, Raleigh, NC 27695, USADepartment of Entomology and Plant Pathology, Campus Box 7647, 3230 Ligon Street, North Carolina State University, Raleigh, NC 27695, USAMosquito-borne malaria kills 429,000 people each year with the problem being acute in sub-Saharan Africa. The successes gained with long-lasting pyrethroid-treated bednets are now in jeopardy because of wide-spread, pyrethroid resistance in mosquitoes. Using crowd modeling theory normalized for standard bednet architecture, we were able to design an attract–trap–kill technology for mosquitoes that does not require insecticides. Using three-dimensional polyester knitting and heat fixation, trap funnels were developed with high capture efficacy with no egression under worst-case laboratory conditions. Field testing in Africa in WHO huts with Gen1-3 T (trap)-Nets validated our model, and as predicted, Gen3 had the highest efficacy with a 4.3-fold greater trap–kill rate with no deterrence or repellency compared to Permanet 2.0, the most common bednet in Africa. A T-Net population model was developed based on field data to predict community-level mosquito control compared to a pyrethroid bednet. This model showed the Gen3 non-insecticidal T-Net under field conditions in Africa against pyrethroid resistant mosquitoes was 12.7-fold more efficacious than single chemical, pyrethroid-treated nets.https://www.mdpi.com/2075-4450/11/11/732malariavector controlinsecticide resistancelong-lasting bednetvector control failuretrapping bednet |
| spellingShingle | Chouaibou S. Mouhamadou Kun Luan Behi K. Fodjo Andre J. West Marian G. McCord Charles S. Apperson R. Michael Roe Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of Thinking Insects malaria vector control insecticide resistance long-lasting bednet vector control failure trapping bednet |
| title | Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of Thinking |
| title_full | Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of Thinking |
| title_fullStr | Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of Thinking |
| title_full_unstemmed | Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of Thinking |
| title_short | Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of Thinking |
| title_sort | development of an insecticide free trapping bednet to control mosquitoes and manage resistance in malaria vector control a new way of thinking |
| topic | malaria vector control insecticide resistance long-lasting bednet vector control failure trapping bednet |
| url | https://www.mdpi.com/2075-4450/11/11/732 |
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