Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapy
Abstract Graphdiyne has excellent potential due to its enzymatic properties. Metal-free sulfur-doped Graphdiyne (S-GDY) has piezoelectric characteristics, and ultrasonic excitation of S-GDY enhances peroxidase activity. It can turn hydrogen peroxide into toxic hydroxyl radicals and induce apoptosis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02059-y |
| _version_ | 1797556753306484736 |
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| author | Jianxin Wang Yinzhu Chu Zhiyu Zhao Cong Zhang Qi Chen Haitao Ran Yang Cao Changjun Wu |
| author_facet | Jianxin Wang Yinzhu Chu Zhiyu Zhao Cong Zhang Qi Chen Haitao Ran Yang Cao Changjun Wu |
| author_sort | Jianxin Wang |
| collection | DOAJ |
| description | Abstract Graphdiyne has excellent potential due to its enzymatic properties. Metal-free sulfur-doped Graphdiyne (S-GDY) has piezoelectric characteristics, and ultrasonic excitation of S-GDY enhances peroxidase activity. It can turn hydrogen peroxide into toxic hydroxyl radicals and induce apoptosis in 4T1 cells. More importantly, the ultrasound (US) enhanced nanozyme induced 4T1 cell ferroptosis by promoting an imbalanced redox reaction due to glutathione depletion and glutathione peroxidase 4 inactivation. S-GDY exhibited enhanced nanozyme activity in vitro and in vivo that may directly trigger apoptosis-ferroptosis for effective tumor therapy. Altogether, this study was expected to provide new insights into the design of piezoelectric catalytic nanozyme and expand their application in the catalytic therapy of tumors. Graphical Abstract |
| first_indexed | 2024-03-10T17:07:22Z |
| format | Article |
| id | doaj.art-ec7955f58a364b3d986db1755ec785e8 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-10T17:07:22Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-ec7955f58a364b3d986db1755ec785e82023-11-20T10:47:45ZengBMCJournal of Nanobiotechnology1477-31552023-09-0121111210.1186/s12951-023-02059-yPiezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapyJianxin Wang0Yinzhu Chu1Zhiyu Zhao2Cong Zhang3Qi Chen4Haitao Ran5Yang Cao6Changjun Wu7Department of Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityChongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Second Affiliated Hospital, State Key Laboratory of Ultrasound in Medicine and Engineering,, Chongqing Medical UniversityChongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Second Affiliated Hospital, State Key Laboratory of Ultrasound in Medicine and Engineering,, Chongqing Medical UniversityDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityAbstract Graphdiyne has excellent potential due to its enzymatic properties. Metal-free sulfur-doped Graphdiyne (S-GDY) has piezoelectric characteristics, and ultrasonic excitation of S-GDY enhances peroxidase activity. It can turn hydrogen peroxide into toxic hydroxyl radicals and induce apoptosis in 4T1 cells. More importantly, the ultrasound (US) enhanced nanozyme induced 4T1 cell ferroptosis by promoting an imbalanced redox reaction due to glutathione depletion and glutathione peroxidase 4 inactivation. S-GDY exhibited enhanced nanozyme activity in vitro and in vivo that may directly trigger apoptosis-ferroptosis for effective tumor therapy. Altogether, this study was expected to provide new insights into the design of piezoelectric catalytic nanozyme and expand their application in the catalytic therapy of tumors. Graphical Abstracthttps://doi.org/10.1186/s12951-023-02059-yGraphdiyneNanozymesFerroptosisUltrasoundPiezoelectric catalytic therapy |
| spellingShingle | Jianxin Wang Yinzhu Chu Zhiyu Zhao Cong Zhang Qi Chen Haitao Ran Yang Cao Changjun Wu Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapy Journal of Nanobiotechnology Graphdiyne Nanozymes Ferroptosis Ultrasound Piezoelectric catalytic therapy |
| title | Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapy |
| title_full | Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapy |
| title_fullStr | Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapy |
| title_full_unstemmed | Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapy |
| title_short | Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapy |
| title_sort | piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis apoptosis anticancer therapy |
| topic | Graphdiyne Nanozymes Ferroptosis Ultrasound Piezoelectric catalytic therapy |
| url | https://doi.org/10.1186/s12951-023-02059-y |
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