The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and <i>Cynara cardunculus</i> L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice
Obesity is one of the world’s most serious public health issues, with a high risk of developing a wide range of diseases. As a result, focusing on adipose tissue dysfunction may help to prevent the metabolic disturbances commonly associated with obesity. Nutraceutical supplementation may be a crucia...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/191 |
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| author | Saverio Nucera Federica Scarano Roberta Macrì Rocco Mollace Micaela Gliozzi Cristina Carresi Stefano Ruga Maria Serra Annamaria Tavernese Rosamaria Caminiti Annarita Coppoletta Antonio Cardamone Tiziana Montalcini Arturo Pujia Ernesto Palma Carolina Muscoli Francesco Barillà Vincenzo Musolino Vincenzo Mollace |
| author_facet | Saverio Nucera Federica Scarano Roberta Macrì Rocco Mollace Micaela Gliozzi Cristina Carresi Stefano Ruga Maria Serra Annamaria Tavernese Rosamaria Caminiti Annarita Coppoletta Antonio Cardamone Tiziana Montalcini Arturo Pujia Ernesto Palma Carolina Muscoli Francesco Barillà Vincenzo Musolino Vincenzo Mollace |
| author_sort | Saverio Nucera |
| collection | DOAJ |
| description | Obesity is one of the world’s most serious public health issues, with a high risk of developing a wide range of diseases. As a result, focusing on adipose tissue dysfunction may help to prevent the metabolic disturbances commonly associated with obesity. Nutraceutical supplementation may be a crucial strategy for improving WAT inflammation and obesity and accelerating the browning process. The aim of this study was to perform a preclinical “proof of concept” study on <i>Bergacyn<sup>®</sup></i>, an innovative formulation originating from a combination of bergamot polyphenolic fraction (BPF) and <i>Cynara cardunculus</i> (CyC), for the treatment of adipose tissue dysfunction. In particular, <i>Bergacyn<sup>®</sup></i> supplementation in WD/SW-fed mice at doses of 50 mg/kg given orally for 12 weeks, was able to reduce body weight and total fat mass in the WD/SW mice, in association with an improvement in plasma biochemical parameters, including glycemia, total cholesterol, and LDL levels. In addition, a significant reduction in serum ALT levels was highlighted. The decreased WAT levels corresponded to an increased weight of BAT tissue, which was associated with a downregulation of PPARγ as compared to the vehicle group. <i>Bergacyn<sup>®</sup></i> was able to restore PPARγ levels and prevent NF-kB overexpression in the WAT of mice fed a WD/SW diet, suggesting an improved oxidative metabolism and inflammatory status. These results were associated with a significant potentiation of the total antioxidant status in WD/SW mice. Finally, our data show, for the first time, that <i>Bergacyn</i><sup>®</sup> supplementation may be a valuable approach to counteract adipose tissue dysfunction and obesity-associated effects on cardiometabolic risk. |
| first_indexed | 2024-03-08T15:06:53Z |
| format | Article |
| id | doaj.art-ec7e6e6868614e0bb72beba41d0ed68e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:06:53Z |
| publishDate | 2023-12-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ec7e6e6868614e0bb72beba41d0ed68e2024-01-10T14:58:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125119110.3390/ijms25010191The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and <i>Cynara cardunculus</i> L. Extract on Weight Gain Reduction and Fat Browning in Obese MiceSaverio Nucera0Federica Scarano1Roberta Macrì2Rocco Mollace3Micaela Gliozzi4Cristina Carresi5Stefano Ruga6Maria Serra7Annamaria Tavernese8Rosamaria Caminiti9Annarita Coppoletta10Antonio Cardamone11Tiziana Montalcini12Arturo Pujia13Ernesto Palma14Carolina Muscoli15Francesco Barillà16Vincenzo Musolino17Vincenzo Mollace18Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyVeterinary Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyClinical Nutrition Unit, Department of Clinical and Experimental Medicine, University Magna of Græcia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, ItalyVeterinary Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyPharmaceutical Biology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyObesity is one of the world’s most serious public health issues, with a high risk of developing a wide range of diseases. As a result, focusing on adipose tissue dysfunction may help to prevent the metabolic disturbances commonly associated with obesity. Nutraceutical supplementation may be a crucial strategy for improving WAT inflammation and obesity and accelerating the browning process. The aim of this study was to perform a preclinical “proof of concept” study on <i>Bergacyn<sup>®</sup></i>, an innovative formulation originating from a combination of bergamot polyphenolic fraction (BPF) and <i>Cynara cardunculus</i> (CyC), for the treatment of adipose tissue dysfunction. In particular, <i>Bergacyn<sup>®</sup></i> supplementation in WD/SW-fed mice at doses of 50 mg/kg given orally for 12 weeks, was able to reduce body weight and total fat mass in the WD/SW mice, in association with an improvement in plasma biochemical parameters, including glycemia, total cholesterol, and LDL levels. In addition, a significant reduction in serum ALT levels was highlighted. The decreased WAT levels corresponded to an increased weight of BAT tissue, which was associated with a downregulation of PPARγ as compared to the vehicle group. <i>Bergacyn<sup>®</sup></i> was able to restore PPARγ levels and prevent NF-kB overexpression in the WAT of mice fed a WD/SW diet, suggesting an improved oxidative metabolism and inflammatory status. These results were associated with a significant potentiation of the total antioxidant status in WD/SW mice. Finally, our data show, for the first time, that <i>Bergacyn</i><sup>®</sup> supplementation may be a valuable approach to counteract adipose tissue dysfunction and obesity-associated effects on cardiometabolic risk.https://www.mdpi.com/1422-0067/25/1/191WATBATadipose tissue dysfunctioninflammationoxidative stressnutraceuticals |
| spellingShingle | Saverio Nucera Federica Scarano Roberta Macrì Rocco Mollace Micaela Gliozzi Cristina Carresi Stefano Ruga Maria Serra Annamaria Tavernese Rosamaria Caminiti Annarita Coppoletta Antonio Cardamone Tiziana Montalcini Arturo Pujia Ernesto Palma Carolina Muscoli Francesco Barillà Vincenzo Musolino Vincenzo Mollace The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and <i>Cynara cardunculus</i> L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice International Journal of Molecular Sciences WAT BAT adipose tissue dysfunction inflammation oxidative stress nutraceuticals |
| title | The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and <i>Cynara cardunculus</i> L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice |
| title_full | The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and <i>Cynara cardunculus</i> L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice |
| title_fullStr | The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and <i>Cynara cardunculus</i> L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice |
| title_full_unstemmed | The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and <i>Cynara cardunculus</i> L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice |
| title_short | The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and <i>Cynara cardunculus</i> L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice |
| title_sort | effect of an innovative combination of bergamot polyphenolic fraction and i cynara cardunculus i l extract on weight gain reduction and fat browning in obese mice |
| topic | WAT BAT adipose tissue dysfunction inflammation oxidative stress nutraceuticals |
| url | https://www.mdpi.com/1422-0067/25/1/191 |
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