Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions
Ten countries have reported pfhrp2/pfhrp3 gene deletions since the first observation of pfhrp2-deleted parasites in 2012. In a previous study (Watson et al., 2017), we characterised the drivers selecting for pfhrp2/3 deletions and mapped the regions in Africa with the greatest selection pressure. In...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-05-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/40339 |
| _version_ | 1811181517794181120 |
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| author | Oliver John Watson Robert Verity Azra C Ghani Tini Garske Jane Cunningham Antoinette Tshefu Melchior K Mwandagalirwa Steven R Meshnick Jonathan B Parr Hannah C Slater |
| author_facet | Oliver John Watson Robert Verity Azra C Ghani Tini Garske Jane Cunningham Antoinette Tshefu Melchior K Mwandagalirwa Steven R Meshnick Jonathan B Parr Hannah C Slater |
| author_sort | Oliver John Watson |
| collection | DOAJ |
| description | Ten countries have reported pfhrp2/pfhrp3 gene deletions since the first observation of pfhrp2-deleted parasites in 2012. In a previous study (Watson et al., 2017), we characterised the drivers selecting for pfhrp2/3 deletions and mapped the regions in Africa with the greatest selection pressure. In February 2018, the World Health Organization issued guidance on investigating suspected false-negative rapid diagnostic tests (RDTs) due to pfhrp2/3 deletions. However, no guidance is provided regarding the timing of investigations. Failure to consider seasonal variation could cause premature decisions to switch to alternative RDTs. In response, we have extended our methods and predict that the prevalence of false-negative RDTs due to pfhrp2/3 deletions is highest when sampling from younger individuals during the beginning of the rainy season. We conclude by producing a map of the regions impacted by seasonal fluctuations in pfhrp2/3 deletions and a database identifying optimum sampling intervals to support malaria control programmes. |
| first_indexed | 2024-04-11T09:18:44Z |
| format | Article |
| id | doaj.art-ec7f18e440e7433daad632926d7913ad |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:18:44Z |
| publishDate | 2019-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ec7f18e440e7433daad632926d7913ad2022-12-22T04:32:15ZengeLife Sciences Publications LtdeLife2050-084X2019-05-01810.7554/eLife.40339Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletionsOliver John Watson0https://orcid.org/0000-0003-2374-0741Robert Verity1Azra C Ghani2Tini Garske3Jane Cunningham4Antoinette Tshefu5Melchior K Mwandagalirwa6Steven R Meshnick7Jonathan B Parr8Hannah C Slater9MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United KingdomMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United KingdomMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United KingdomMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United KingdomGlobal Malaria Programme, World Health Organization, Geneva, SwitzerlandSchool of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the CongoSchool of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo; Department of Epidemiology, Gillings School for Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United StatesDepartment of Epidemiology, Gillings School for Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States; Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United StatesDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United StatesMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United KingdomTen countries have reported pfhrp2/pfhrp3 gene deletions since the first observation of pfhrp2-deleted parasites in 2012. In a previous study (Watson et al., 2017), we characterised the drivers selecting for pfhrp2/3 deletions and mapped the regions in Africa with the greatest selection pressure. In February 2018, the World Health Organization issued guidance on investigating suspected false-negative rapid diagnostic tests (RDTs) due to pfhrp2/3 deletions. However, no guidance is provided regarding the timing of investigations. Failure to consider seasonal variation could cause premature decisions to switch to alternative RDTs. In response, we have extended our methods and predict that the prevalence of false-negative RDTs due to pfhrp2/3 deletions is highest when sampling from younger individuals during the beginning of the rainy season. We conclude by producing a map of the regions impacted by seasonal fluctuations in pfhrp2/3 deletions and a database identifying optimum sampling intervals to support malaria control programmes.https://elifesciences.org/articles/40339radid diagnostic testspfhrp2-deletionmappingmathematical modelling |
| spellingShingle | Oliver John Watson Robert Verity Azra C Ghani Tini Garske Jane Cunningham Antoinette Tshefu Melchior K Mwandagalirwa Steven R Meshnick Jonathan B Parr Hannah C Slater Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions eLife radid diagnostic tests pfhrp2-deletion mapping mathematical modelling |
| title | Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions |
| title_full | Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions |
| title_fullStr | Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions |
| title_full_unstemmed | Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions |
| title_short | Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions |
| title_sort | impact of seasonal variations in plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions |
| topic | radid diagnostic tests pfhrp2-deletion mapping mathematical modelling |
| url | https://elifesciences.org/articles/40339 |
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