Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma
This review discusses the microenvironment of evolving and established conventional oral squamous cell carcinoma, by far the most common oral cancer. The focus of this paper is mainly on the more recent data that describe the role of microorganisms, host-microbial interactions, and in particular, th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Oral Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2021.739499/full |
| _version_ | 1830139818804248576 |
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| author | Zoya Kurago Zoya Kurago Zoya Kurago Jenni Loveless |
| author_facet | Zoya Kurago Zoya Kurago Zoya Kurago Jenni Loveless |
| author_sort | Zoya Kurago |
| collection | DOAJ |
| description | This review discusses the microenvironment of evolving and established conventional oral squamous cell carcinoma, by far the most common oral cancer. The focus of this paper is mainly on the more recent data that describe the role of microorganisms, host-microbial interactions, and in particular, the contributions of cell-surface toll-like receptors on immune system cells and on normal and malignant epithelial cells to their functions that support carcinogenesis. Because carcinomas arising at various host surfaces share much in common, additional information available from studies of other carcinomas is included in the discussion. Accumulating evidence reveals the complex toll-like receptor-mediated tumor-supporting input into many aspects of carcinogenesis via malignant cells, stromal immune cells and non-immune cells, complicating the search for effective treatments. |
| first_indexed | 2024-12-17T08:51:07Z |
| format | Article |
| id | doaj.art-ec7f4a3d7c6a4456a0030c1333aa3c1d |
| institution | Directory Open Access Journal |
| issn | 2673-4842 |
| language | English |
| last_indexed | 2024-12-17T08:51:07Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj.art-ec7f4a3d7c6a4456a0030c1333aa3c1d2022-12-21T21:56:05ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422021-10-01210.3389/froh.2021.739499739499Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell CarcinomaZoya Kurago0Zoya Kurago1Zoya Kurago2Jenni Loveless3Augusta University Dental College of Georgia, Augusta, GA, United StatesMedical College of Georgia, Augusta, GA, United StatesGeorgia Cancer Center, Augusta, GA, United StatesAugusta University Dental College of Georgia, Augusta, GA, United StatesThis review discusses the microenvironment of evolving and established conventional oral squamous cell carcinoma, by far the most common oral cancer. The focus of this paper is mainly on the more recent data that describe the role of microorganisms, host-microbial interactions, and in particular, the contributions of cell-surface toll-like receptors on immune system cells and on normal and malignant epithelial cells to their functions that support carcinogenesis. Because carcinomas arising at various host surfaces share much in common, additional information available from studies of other carcinomas is included in the discussion. Accumulating evidence reveals the complex toll-like receptor-mediated tumor-supporting input into many aspects of carcinogenesis via malignant cells, stromal immune cells and non-immune cells, complicating the search for effective treatments.https://www.frontiersin.org/articles/10.3389/froh.2021.739499/fullmicrobiometoll-like receptorsoral squamous cell carcinomaoral epithelial dysplasiainflammationcarcinogenesis |
| spellingShingle | Zoya Kurago Zoya Kurago Zoya Kurago Jenni Loveless Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma Frontiers in Oral Health microbiome toll-like receptors oral squamous cell carcinoma oral epithelial dysplasia inflammation carcinogenesis |
| title | Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma |
| title_full | Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma |
| title_fullStr | Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma |
| title_short | Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma |
| title_sort | microbial colonization and inflammation as potential contributors to the lack of therapeutic success in oral squamous cell carcinoma |
| topic | microbiome toll-like receptors oral squamous cell carcinoma oral epithelial dysplasia inflammation carcinogenesis |
| url | https://www.frontiersin.org/articles/10.3389/froh.2021.739499/full |
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