Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats
Brief episodes of myocardial ischemia-reperfusion (IR) employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of ischemic postco...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/4/3805/ |
| _version_ | 1819161708617269248 |
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| author | Jiangwei Ma Li Zhang Huajin Liu |
| author_facet | Jiangwei Ma Li Zhang Huajin Liu |
| author_sort | Jiangwei Ma |
| collection | DOAJ |
| description | Brief episodes of myocardial ischemia-reperfusion (IR) employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of ischemic postconditioning on an ischemic reperfusion (IR)-induced myocardium oxidative injury in rat model. Results showed that ischemic postconditioning could improve arrhythmia cordis, reduce myocardium infarction and serum creatin kinase (CK), lactate dehydrogenase (LDH) and aspartate transaminase (AST) activities in IR rats. In addition, ischemic postconditioning could still decrease myocardium malondialdehyde (MDA) level, and increased myocardium Na+-K+-ATPase, Ca2+-Mg2+-ATPase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) activities. It can be concluded that ischemic postconditioning possesses strong protective effects against ischemia reperfusion-induced myocardium oxidative injury in IR rats. |
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| format | Article |
| id | doaj.art-ec811df479fd49f5a2f811c20ea49177 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T17:16:38Z |
| publishDate | 2012-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ec811df479fd49f5a2f811c20ea491772022-12-21T18:18:57ZengMDPI AGMolecules1420-30492012-03-011743805381710.3390/molecules17043805Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR RatsJiangwei MaLi ZhangHuajin LiuBrief episodes of myocardial ischemia-reperfusion (IR) employed during reperfusion after a prolonged ischemic insult may attenuate the total ischemia-reperfusion injury. This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of ischemic postconditioning on an ischemic reperfusion (IR)-induced myocardium oxidative injury in rat model. Results showed that ischemic postconditioning could improve arrhythmia cordis, reduce myocardium infarction and serum creatin kinase (CK), lactate dehydrogenase (LDH) and aspartate transaminase (AST) activities in IR rats. In addition, ischemic postconditioning could still decrease myocardium malondialdehyde (MDA) level, and increased myocardium Na+-K+-ATPase, Ca2+-Mg2+-ATPase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) activities. It can be concluded that ischemic postconditioning possesses strong protective effects against ischemia reperfusion-induced myocardium oxidative injury in IR rats.http://www.mdpi.com/1420-3049/17/4/3805/ischemia-reperfusionischemic postconditioningmyocardiumoxidative injury |
| spellingShingle | Jiangwei Ma Li Zhang Huajin Liu Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats Molecules ischemia-reperfusion ischemic postconditioning myocardium oxidative injury |
| title | Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats |
| title_full | Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats |
| title_fullStr | Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats |
| title_full_unstemmed | Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats |
| title_short | Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats |
| title_sort | protective effect of ischemic postconditioning against ischemia reperfusion induced myocardium oxidative injury in ir rats |
| topic | ischemia-reperfusion ischemic postconditioning myocardium oxidative injury |
| url | http://www.mdpi.com/1420-3049/17/4/3805/ |
| work_keys_str_mv | AT jiangweima protectiveeffectofischemicpostconditioningagainstischemiareperfusioninducedmyocardiumoxidativeinjuryinirrats AT lizhang protectiveeffectofischemicpostconditioningagainstischemiareperfusioninducedmyocardiumoxidativeinjuryinirrats AT huajinliu protectiveeffectofischemicpostconditioningagainstischemiareperfusioninducedmyocardiumoxidativeinjuryinirrats |