Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study

<h4>Background</h4> HIV is a leading cause of morbidity and mortality in South Africa that can be managed using antiretroviral therapy (ART). Adherence clubs are interventions that have been introduced to decentralize ART to improve ART adherence and provide social support for club membe...

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Main Authors: Tariro Ndoro, Ntombizodwa Ndlovu, Peter Nyasulu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624407/?tool=EBI
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author Tariro Ndoro
Ntombizodwa Ndlovu
Peter Nyasulu
author_facet Tariro Ndoro
Ntombizodwa Ndlovu
Peter Nyasulu
author_sort Tariro Ndoro
collection DOAJ
description <h4>Background</h4> HIV is a leading cause of morbidity and mortality in South Africa that can be managed using antiretroviral therapy (ART). Adherence clubs are interventions that have been introduced to decentralize ART to improve ART adherence and provide social support for club members. However, ART adherence can be suboptimal even among adherence club members. <h4>Aim</h4> This study aimed to determine the factors affecting ART adherence among people living with HIV/AIDS (PLWHA) attending adherence clubs in Ekurhuleni Metropolitan Municipality. <h4>Methods</h4> A cross-sectional study was conducted. Ordinal logistic regression was used in univariable and multivariable analyses to determine factors significantly associated with adherence scores. Factors included in the final model were age, comorbidity, ART regimen and club membership duration. <h4>Results</h4> The records of 730 participants were analysed. After adjusting for age, participants with comorbidities were half as likely to report high ART adherence scores compared to participants without comorbidities (AOR = 0.5, 95% CI: 0.3–0.8, p = 0.005). The adjusted odds of reporting high levels of adherence among participants on cART were 1.8 times those on a single tablet regimen (AOR = 1.8, 95% CI: 1.0–3.2; p = 0.033). There was a 20% reduction in the adjusted odds of reporting high ART adherence for each additional year of adherence club membership (AOR = 0.8, 95% CI: 0.8–0.9, p<0.001). <h4>Conclusion</h4> Increasing years spent as adherence club members, single tablet ART regimens and the presence of comorbidities were all significantly associated with low ART adherence among study participants. Regular assessment of the quality of counselling sessions for ART adherence club members and questionnaires for early screening of treatment fatigue have been suggested as tools for improved adherence in ART adherence club settings.
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spelling doaj.art-ec82c4cf8f9246dab61cbd7b13f324392022-12-22T02:38:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional studyTariro NdoroNtombizodwa NdlovuPeter Nyasulu<h4>Background</h4> HIV is a leading cause of morbidity and mortality in South Africa that can be managed using antiretroviral therapy (ART). Adherence clubs are interventions that have been introduced to decentralize ART to improve ART adherence and provide social support for club members. However, ART adherence can be suboptimal even among adherence club members. <h4>Aim</h4> This study aimed to determine the factors affecting ART adherence among people living with HIV/AIDS (PLWHA) attending adherence clubs in Ekurhuleni Metropolitan Municipality. <h4>Methods</h4> A cross-sectional study was conducted. Ordinal logistic regression was used in univariable and multivariable analyses to determine factors significantly associated with adherence scores. Factors included in the final model were age, comorbidity, ART regimen and club membership duration. <h4>Results</h4> The records of 730 participants were analysed. After adjusting for age, participants with comorbidities were half as likely to report high ART adherence scores compared to participants without comorbidities (AOR = 0.5, 95% CI: 0.3–0.8, p = 0.005). The adjusted odds of reporting high levels of adherence among participants on cART were 1.8 times those on a single tablet regimen (AOR = 1.8, 95% CI: 1.0–3.2; p = 0.033). There was a 20% reduction in the adjusted odds of reporting high ART adherence for each additional year of adherence club membership (AOR = 0.8, 95% CI: 0.8–0.9, p<0.001). <h4>Conclusion</h4> Increasing years spent as adherence club members, single tablet ART regimens and the presence of comorbidities were all significantly associated with low ART adherence among study participants. Regular assessment of the quality of counselling sessions for ART adherence club members and questionnaires for early screening of treatment fatigue have been suggested as tools for improved adherence in ART adherence club settings.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624407/?tool=EBI
spellingShingle Tariro Ndoro
Ntombizodwa Ndlovu
Peter Nyasulu
Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study
PLoS ONE
title Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study
title_full Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study
title_fullStr Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study
title_full_unstemmed Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study
title_short Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study
title_sort factors associated with art adherence among hiv positive adherence club members in ekurhuleni metropolitan municipality south africa a cross sectional study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624407/?tool=EBI
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AT ntombizodwandlovu factorsassociatedwithartadherenceamonghivpositiveadherenceclubmembersinekurhulenimetropolitanmunicipalitysouthafricaacrosssectionalstudy
AT peternyasulu factorsassociatedwithartadherenceamonghivpositiveadherenceclubmembersinekurhulenimetropolitanmunicipalitysouthafricaacrosssectionalstudy