Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function.

Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function.

During vertebrate cardiac development NOTCH signaling activity in the endocardium is essential for the crosstalk between endocardium and myocardium that initiates ventricular trabeculation and valve primordium formation. This crosstalk leads later to the maturation and compaction of the ventricular...

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Bibliographic Details
Main Authors: Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Gaetano D'Amato, Luis J Jiménez-Borreguero, José Luis de la Pompa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0203100

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