Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopenia
Introduction Heparin‐induced thrombocytopenia is an antibody‐mediated acquired prothrombotic state induced by heparin exposure. The risk of thromboembolic diseases in kidney transplantation with heparin‐induced thrombocytopenia without perioperative anticoagulation has not been determined. Case pres...
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| Format: | Article |
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Wiley
2020-05-01
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| Series: | IJU Case Reports |
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| Online Access: | https://doi.org/10.1002/iju5.12148 |
| _version_ | 1818160199652868096 |
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| author | Hayato Nishida Hiroki Fukuhara Atsushi Yamagishi Noriyuki Hosoya Osamu Ichiyanagi Toshihiko Sakurai Sei Naito Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya |
| author_facet | Hayato Nishida Hiroki Fukuhara Atsushi Yamagishi Noriyuki Hosoya Osamu Ichiyanagi Toshihiko Sakurai Sei Naito Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya |
| author_sort | Hayato Nishida |
| collection | DOAJ |
| description | Introduction Heparin‐induced thrombocytopenia is an antibody‐mediated acquired prothrombotic state induced by heparin exposure. The risk of thromboembolic diseases in kidney transplantation with heparin‐induced thrombocytopenia without perioperative anticoagulation has not been determined. Case presentation A 64‐year‐old male hemodialysis patient with heparin‐induced thrombocytopenia was referred to our hospital for living kidney transplantation. Anti‐heparin‐induced thrombocytopenia antibody was positive at the time of referral; however, it turned negative 4 months after heparin cessation during hemodialysis sessions. Living kidney transplantation by donation from his wife was performed using the standard technical procedure. Both heparinization and application of medical equipment containing heparin were avoided; however, no anticoagulant was administered intra‐ and postoperatively. The graft kidney functioned immediately, and no thromboembolic event related to heparin‐induced thrombocytopenia occurred. Conclusion Kidney transplantation without perioperative anticoagulation therapy after disappearance of anti‐heparin‐induced thrombocytopenia antibody is a well‐tolerated treatment option for patients with end‐stage kidney disease. |
| first_indexed | 2024-12-11T15:58:05Z |
| format | Article |
| id | doaj.art-ec83015b14844c239318a314c26b03cf |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-12-11T15:58:05Z |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-ec83015b14844c239318a314c26b03cf2022-12-22T00:59:22ZengWileyIJU Case Reports2577-171X2020-05-0133868910.1002/iju5.12148Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopeniaHayato Nishida0Hiroki Fukuhara1Atsushi Yamagishi2Noriyuki Hosoya3Osamu Ichiyanagi4Toshihiko Sakurai5Sei Naito6Takuya Yamanobe7Tomoyuki Kato8Norihiko Tsuchiya9Department of Urology Yamagata University Faculty of Medicine Yamagata JapanDepartment of Urology Yamagata University Faculty of Medicine Yamagata JapanDepartment of Urology Yamagata University Faculty of Medicine Yamagata JapanDepartment of Urology Tsuruoka Municipal Shonai Hospital Yamagata JapanDepartment of Urology Yamagata Prefectural Kahoku Hospital Yamagata JapanDepartment of Urology Yamagata University Faculty of Medicine Yamagata JapanDepartment of Urology Yamagata University Faculty of Medicine Yamagata JapanDepartment of Urology Yamagata University Faculty of Medicine Yamagata JapanDepartment of Urology Yamagata University Faculty of Medicine Yamagata JapanDepartment of Urology Yamagata University Faculty of Medicine Yamagata JapanIntroduction Heparin‐induced thrombocytopenia is an antibody‐mediated acquired prothrombotic state induced by heparin exposure. The risk of thromboembolic diseases in kidney transplantation with heparin‐induced thrombocytopenia without perioperative anticoagulation has not been determined. Case presentation A 64‐year‐old male hemodialysis patient with heparin‐induced thrombocytopenia was referred to our hospital for living kidney transplantation. Anti‐heparin‐induced thrombocytopenia antibody was positive at the time of referral; however, it turned negative 4 months after heparin cessation during hemodialysis sessions. Living kidney transplantation by donation from his wife was performed using the standard technical procedure. Both heparinization and application of medical equipment containing heparin were avoided; however, no anticoagulant was administered intra‐ and postoperatively. The graft kidney functioned immediately, and no thromboembolic event related to heparin‐induced thrombocytopenia occurred. Conclusion Kidney transplantation without perioperative anticoagulation therapy after disappearance of anti‐heparin‐induced thrombocytopenia antibody is a well‐tolerated treatment option for patients with end‐stage kidney disease.https://doi.org/10.1002/iju5.12148end‐stage renal diseaseheparinheparin‐induced thrombocytopeniakidney transplantation |
| spellingShingle | Hayato Nishida Hiroki Fukuhara Atsushi Yamagishi Noriyuki Hosoya Osamu Ichiyanagi Toshihiko Sakurai Sei Naito Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopenia IJU Case Reports end‐stage renal disease heparin heparin‐induced thrombocytopenia kidney transplantation |
| title | Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopenia |
| title_full | Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopenia |
| title_fullStr | Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopenia |
| title_full_unstemmed | Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopenia |
| title_short | Living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin‐induced thrombocytopenia |
| title_sort | living kidney transplantation without perioperative anticoagulation therapy for a patient with heparin induced thrombocytopenia |
| topic | end‐stage renal disease heparin heparin‐induced thrombocytopenia kidney transplantation |
| url | https://doi.org/10.1002/iju5.12148 |
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