A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults
Abstract The cluster of differentiation 36 (CD36) is one of the main receptors implicated in the pathogenesis of the cardiovascular disease. This study aimed to assess the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors including body mass index (BMI), waist circumfe...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09908-0 |
| _version_ | 1828734216825733120 |
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| author | Zeinab Yazdanpanah Hassan Mozaffari‐Khosravi Masoud Mirzaei Mohammad Hasan Sheikhha Amin Salehi-Abargouei |
| author_facet | Zeinab Yazdanpanah Hassan Mozaffari‐Khosravi Masoud Mirzaei Mohammad Hasan Sheikhha Amin Salehi-Abargouei |
| author_sort | Zeinab Yazdanpanah |
| collection | DOAJ |
| description | Abstract The cluster of differentiation 36 (CD36) is one of the main receptors implicated in the pathogenesis of the cardiovascular disease. This study aimed to assess the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors including body mass index (BMI), waist circumference (WC), total cholesterol (TC), triglyceride, HDL-C, LDL-C, blood pressure and fasting blood glucose (FBG). PubMed, EMBASE, Scopus, web of science, and Google Scholar were searched up to December 2021. Subgroup and meta-regression analyses were conducted to explore sources of heterogeneity. Eighteen eligible studies (6317 participants) were included in the study. In the overall analysis, a significant association was found between rs1761667 polymorphism of CD36 and TG in allelic (p < 0.001), recessive (p = 0.001) and homozygous (p = 0.006) models. A relationship between this polymorphism and HDL-C and FBG level was observed in the recessive genetic model. In the subgroup analysis, the A allele was associated with impaired lipid profiles (TC, LDL-C and HDL-C) in the Asian population. The influences of health status, design of the study, confounders, and other sources of heterogeneity should be considered when interpreting present findings. Cohort studies with large sample size and in different ethnicities are needed to confirm the relationship between rs1761667 SNP and cardiometabolic risk factors. |
| first_indexed | 2024-04-12T22:44:15Z |
| format | Article |
| id | doaj.art-ec83504a875c464f87d9f0171029bab1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T22:44:15Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ec83504a875c464f87d9f0171029bab12022-12-22T03:13:37ZengNature PortfolioScientific Reports2045-23222022-04-0112111410.1038/s41598-022-09908-0A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adultsZeinab Yazdanpanah0Hassan Mozaffari‐Khosravi1Masoud Mirzaei2Mohammad Hasan Sheikhha3Amin Salehi-Abargouei4Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesYazd Cardiovascular Research Centre, Non-Communicable Research Institute, Shahid Sadoughi University of Medical SciencesDepartment of Medical Genetics, Shahid Sadoughi University of Medical SciencesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesAbstract The cluster of differentiation 36 (CD36) is one of the main receptors implicated in the pathogenesis of the cardiovascular disease. This study aimed to assess the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors including body mass index (BMI), waist circumference (WC), total cholesterol (TC), triglyceride, HDL-C, LDL-C, blood pressure and fasting blood glucose (FBG). PubMed, EMBASE, Scopus, web of science, and Google Scholar were searched up to December 2021. Subgroup and meta-regression analyses were conducted to explore sources of heterogeneity. Eighteen eligible studies (6317 participants) were included in the study. In the overall analysis, a significant association was found between rs1761667 polymorphism of CD36 and TG in allelic (p < 0.001), recessive (p = 0.001) and homozygous (p = 0.006) models. A relationship between this polymorphism and HDL-C and FBG level was observed in the recessive genetic model. In the subgroup analysis, the A allele was associated with impaired lipid profiles (TC, LDL-C and HDL-C) in the Asian population. The influences of health status, design of the study, confounders, and other sources of heterogeneity should be considered when interpreting present findings. Cohort studies with large sample size and in different ethnicities are needed to confirm the relationship between rs1761667 SNP and cardiometabolic risk factors.https://doi.org/10.1038/s41598-022-09908-0 |
| spellingShingle | Zeinab Yazdanpanah Hassan Mozaffari‐Khosravi Masoud Mirzaei Mohammad Hasan Sheikhha Amin Salehi-Abargouei A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults Scientific Reports |
| title | A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults |
| title_full | A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults |
| title_fullStr | A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults |
| title_full_unstemmed | A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults |
| title_short | A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults |
| title_sort | systematic review and meta analysis on the association between cd36 rs1761667 polymorphism and cardiometabolic risk factors in adults |
| url | https://doi.org/10.1038/s41598-022-09908-0 |
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