Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study
BackgroundMany observational studies have been reported that patients with autoimmune or allergic diseases seem to have a higher risk of developing senile cataract, but the views are not consistent. In order to minimize the influence of reverse causality and potential confounding factors, we perform...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325868/full |
| _version_ | 1797249314388443136 |
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| author | Weichen Yuan Weichen Yuan Xiangrui Li Xiangrui Li Guan Wang Guan Wang Bo Qu Bo Qu Fangkun Zhao Fangkun Zhao |
| author_facet | Weichen Yuan Weichen Yuan Xiangrui Li Xiangrui Li Guan Wang Guan Wang Bo Qu Bo Qu Fangkun Zhao Fangkun Zhao |
| author_sort | Weichen Yuan |
| collection | DOAJ |
| description | BackgroundMany observational studies have been reported that patients with autoimmune or allergic diseases seem to have a higher risk of developing senile cataract, but the views are not consistent. In order to minimize the influence of reverse causality and potential confounding factors, we performed Mendelian Randomization (MR) analysis to investigate the genetic causal associations between autoimmune, allergic diseases and senile cataract.MethodsSingle nucleotide polymorphisms associated with ten common autoimmune and allergic diseases were obtained from the IEU Open genome-wide association studies (GWAS) database. Summary-level GWAS statistics for clinically diagnosed senile cataract were obtained from the FinnGen research project GWAS, which consisted of 59,522 individuals with senile cataracts and 312,864 control individuals. MR analysis was conducted using mainly inverse variance weighted (IVW) method and further sensitivity analysis was performed to test robustness.ResultsAs for ten diseases, IVW results confirmed that type 1 diabetes (OR = 1.06; 95% CI = 1.05-1.08; p = 2.24×10-12), rheumatoid arthritis (OR = 1.05; 95% CI = 1.02-1.08; p = 1.83×10-4), hypothyroidism (OR = 2.4; 95% CI = 1.42-4.06; p = 1.12×10-3), systemic lupus erythematosus (OR = 1.02; 95% CI = 1.01-1.03; p = 2.27×10-3), asthma (OR = 1.02; 95% CI = 1.01-1.03; p = 1.2×10-3) and allergic rhinitis (OR = 1.07; 95% CI = 1.02-1.11; p = 2.15×10-3) were correlated with the risk of senile cataract. Celiac disease (OR = 1.04; 95% CI = 1.01-1.08; P = 0.0437) and atopic dermatitis (OR = 1.05; 95% CI = 1.01-1.10; P = 0.0426) exhibited a suggestive connection with senile cataract after Bonferroni correction. These associations are consistent across weighted median and MR Egger methods, with similar causal estimates in direction and magnitude. Sensitivity analysis further proved that these associations were reliable.ConclusionsThe results of the MR analysis showed that there were causal relationships between type 1 diabetes, rheumatoid arthritis, hypothyroidism, systemic lupus erythematosus, asthma, allergic rhinitis and senile cataract. To clarify the possible role of autoimmune and allergy in the pathophysiology of senile cataract, further studies are needed. |
| first_indexed | 2024-04-24T20:28:31Z |
| format | Article |
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| language | English |
| last_indexed | 2024-04-24T20:28:31Z |
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| spelling | doaj.art-ec8407b904d5402588297629ff072d622024-03-22T04:27:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13258681325868Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization studyWeichen Yuan0Weichen Yuan1Xiangrui Li2Xiangrui Li3Guan Wang4Guan Wang5Bo Qu6Bo Qu7Fangkun Zhao8Fangkun Zhao9Department of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaKey Lens Research Laboratory of Liaoning Province, Shenyang, ChinaDepartment of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaKey Lens Research Laboratory of Liaoning Province, Shenyang, ChinaDepartment of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaKey Lens Research Laboratory of Liaoning Province, Shenyang, ChinaDepartment of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaKey Lens Research Laboratory of Liaoning Province, Shenyang, ChinaDepartment of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaKey Lens Research Laboratory of Liaoning Province, Shenyang, ChinaBackgroundMany observational studies have been reported that patients with autoimmune or allergic diseases seem to have a higher risk of developing senile cataract, but the views are not consistent. In order to minimize the influence of reverse causality and potential confounding factors, we performed Mendelian Randomization (MR) analysis to investigate the genetic causal associations between autoimmune, allergic diseases and senile cataract.MethodsSingle nucleotide polymorphisms associated with ten common autoimmune and allergic diseases were obtained from the IEU Open genome-wide association studies (GWAS) database. Summary-level GWAS statistics for clinically diagnosed senile cataract were obtained from the FinnGen research project GWAS, which consisted of 59,522 individuals with senile cataracts and 312,864 control individuals. MR analysis was conducted using mainly inverse variance weighted (IVW) method and further sensitivity analysis was performed to test robustness.ResultsAs for ten diseases, IVW results confirmed that type 1 diabetes (OR = 1.06; 95% CI = 1.05-1.08; p = 2.24×10-12), rheumatoid arthritis (OR = 1.05; 95% CI = 1.02-1.08; p = 1.83×10-4), hypothyroidism (OR = 2.4; 95% CI = 1.42-4.06; p = 1.12×10-3), systemic lupus erythematosus (OR = 1.02; 95% CI = 1.01-1.03; p = 2.27×10-3), asthma (OR = 1.02; 95% CI = 1.01-1.03; p = 1.2×10-3) and allergic rhinitis (OR = 1.07; 95% CI = 1.02-1.11; p = 2.15×10-3) were correlated with the risk of senile cataract. Celiac disease (OR = 1.04; 95% CI = 1.01-1.08; P = 0.0437) and atopic dermatitis (OR = 1.05; 95% CI = 1.01-1.10; P = 0.0426) exhibited a suggestive connection with senile cataract after Bonferroni correction. These associations are consistent across weighted median and MR Egger methods, with similar causal estimates in direction and magnitude. Sensitivity analysis further proved that these associations were reliable.ConclusionsThe results of the MR analysis showed that there were causal relationships between type 1 diabetes, rheumatoid arthritis, hypothyroidism, systemic lupus erythematosus, asthma, allergic rhinitis and senile cataract. To clarify the possible role of autoimmune and allergy in the pathophysiology of senile cataract, further studies are needed.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325868/fullautoimmune diseasesallergyMendelian randomizationsenile cataractGWAS - genome-wide association study |
| spellingShingle | Weichen Yuan Weichen Yuan Xiangrui Li Xiangrui Li Guan Wang Guan Wang Bo Qu Bo Qu Fangkun Zhao Fangkun Zhao Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study Frontiers in Immunology autoimmune diseases allergy Mendelian randomization senile cataract GWAS - genome-wide association study |
| title | Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study |
| title_full | Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study |
| title_fullStr | Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study |
| title_full_unstemmed | Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study |
| title_short | Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study |
| title_sort | association of autoimmune and allergic diseases with senile cataract a bidirectional two sample mendelian randomization study |
| topic | autoimmune diseases allergy Mendelian randomization senile cataract GWAS - genome-wide association study |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325868/full |
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