Polymeric Patches Based on Chitosan/Green Clay Composites and Hazelnut Shell Extract as Bio-Sustainable Medication for Wounds
Hazelnut shells, the main waste deriving from hazelnut processing, represent an interesting source of active molecules useful in pharmaceutics, although they have not yet been examined in depth. A hydrosoluble extract (hazelnut shell extract, HSE) was prepared by the maceration method using a hydroa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/8/2057 |
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| author | Carmen Laura Pérez Gutíerrez Alessandro Di Michele Cinzia Pagano Debora Puglia Francesca Luzi Tommaso Beccari Maria Rachele Ceccarini Sara Primavilla Andrea Valiani Camilla Vicino Maurizio Ricci César Antonio Viseras Iborra Luana Perioli |
| author_facet | Carmen Laura Pérez Gutíerrez Alessandro Di Michele Cinzia Pagano Debora Puglia Francesca Luzi Tommaso Beccari Maria Rachele Ceccarini Sara Primavilla Andrea Valiani Camilla Vicino Maurizio Ricci César Antonio Viseras Iborra Luana Perioli |
| author_sort | Carmen Laura Pérez Gutíerrez |
| collection | DOAJ |
| description | Hazelnut shells, the main waste deriving from hazelnut processing, represent an interesting source of active molecules useful in pharmaceutics, although they have not yet been examined in depth. A hydrosoluble extract (hazelnut shell extract, HSE) was prepared by the maceration method using a hydroalcoholic solution and used as the active ingredient of patches (prepared by casting method) consisting of composites of highly deacetylated chitosan and green clay. In vitro studies showed that the formulation containing HSE is able to stimulate keratinocyte growth, which is useful for healing purposes, and to inhibit the growth of <i>S. aureus</i> (Log CFU/mL 0.95 vs. 8.85 of the control after 48 h); this bacterium is often responsible for wound infections and is difficult to treat by conventional antibiotics due to its antibiotic resistance. The produced patches showed suitable tensile properties that are necessary to withstand mechanical stress during both the removal from the packaging and application. The obtained results suggest that the developed patch could be a suitable product to treat wounds. |
| first_indexed | 2024-03-10T23:40:03Z |
| format | Article |
| id | doaj.art-ec8595a7415a499ebd22b5ed8432f0cf |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:40:03Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-ec8595a7415a499ebd22b5ed8432f0cf2023-11-19T02:36:05ZengMDPI AGPharmaceutics1999-49232023-07-01158205710.3390/pharmaceutics15082057Polymeric Patches Based on Chitosan/Green Clay Composites and Hazelnut Shell Extract as Bio-Sustainable Medication for WoundsCarmen Laura Pérez Gutíerrez0Alessandro Di Michele1Cinzia Pagano2Debora Puglia3Francesca Luzi4Tommaso Beccari5Maria Rachele Ceccarini6Sara Primavilla7Andrea Valiani8Camilla Vicino9Maurizio Ricci10César Antonio Viseras Iborra11Luana Perioli12Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Physics and Geology, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Civil and Environmental Engineering, University of Perugia, UdR INSTM, 05100 Terni, ItalyDepartment of Materials, Environmental Sciences and Urban Planning (SIMAU), Polytechnic University of Marche, 60131 Ancona, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyIstituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”, 06126 Perugia, ItalyIstituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”, 06126 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18016 Granada, SpainDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyHazelnut shells, the main waste deriving from hazelnut processing, represent an interesting source of active molecules useful in pharmaceutics, although they have not yet been examined in depth. A hydrosoluble extract (hazelnut shell extract, HSE) was prepared by the maceration method using a hydroalcoholic solution and used as the active ingredient of patches (prepared by casting method) consisting of composites of highly deacetylated chitosan and green clay. In vitro studies showed that the formulation containing HSE is able to stimulate keratinocyte growth, which is useful for healing purposes, and to inhibit the growth of <i>S. aureus</i> (Log CFU/mL 0.95 vs. 8.85 of the control after 48 h); this bacterium is often responsible for wound infections and is difficult to treat by conventional antibiotics due to its antibiotic resistance. The produced patches showed suitable tensile properties that are necessary to withstand mechanical stress during both the removal from the packaging and application. The obtained results suggest that the developed patch could be a suitable product to treat wounds.https://www.mdpi.com/1999-4923/15/8/2057hazelnut shell extractchitosangreen claybioadhesionwoundssustainability |
| spellingShingle | Carmen Laura Pérez Gutíerrez Alessandro Di Michele Cinzia Pagano Debora Puglia Francesca Luzi Tommaso Beccari Maria Rachele Ceccarini Sara Primavilla Andrea Valiani Camilla Vicino Maurizio Ricci César Antonio Viseras Iborra Luana Perioli Polymeric Patches Based on Chitosan/Green Clay Composites and Hazelnut Shell Extract as Bio-Sustainable Medication for Wounds Pharmaceutics hazelnut shell extract chitosan green clay bioadhesion wounds sustainability |
| title | Polymeric Patches Based on Chitosan/Green Clay Composites and Hazelnut Shell Extract as Bio-Sustainable Medication for Wounds |
| title_full | Polymeric Patches Based on Chitosan/Green Clay Composites and Hazelnut Shell Extract as Bio-Sustainable Medication for Wounds |
| title_fullStr | Polymeric Patches Based on Chitosan/Green Clay Composites and Hazelnut Shell Extract as Bio-Sustainable Medication for Wounds |
| title_full_unstemmed | Polymeric Patches Based on Chitosan/Green Clay Composites and Hazelnut Shell Extract as Bio-Sustainable Medication for Wounds |
| title_short | Polymeric Patches Based on Chitosan/Green Clay Composites and Hazelnut Shell Extract as Bio-Sustainable Medication for Wounds |
| title_sort | polymeric patches based on chitosan green clay composites and hazelnut shell extract as bio sustainable medication for wounds |
| topic | hazelnut shell extract chitosan green clay bioadhesion wounds sustainability |
| url | https://www.mdpi.com/1999-4923/15/8/2057 |
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