Bioactivity of neolignans from fructus Schizandrae
Fructus Schisandrae sinensis Baill, a traditional Chinese medicine, used as tonic and sedative, has been shown at the beginning of 70's to lower the elevated serum glutamic-pyruvic transaminase (SGPT) levels of patients suffering from chronic viral hepatitis. Durign past 20 years, a series of n...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1991-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600010 |
| _version_ | 1797756674635726848 |
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| author | Xiao-Yu Li |
| author_facet | Xiao-Yu Li |
| author_sort | Xiao-Yu Li |
| collection | DOAJ |
| description | Fructus Schisandrae sinensis Baill, a traditional Chinese medicine, used as tonic and sedative, has been shown at the beginning of 70's to lower the elevated serum glutamic-pyruvic transaminase (SGPT) levels of patients suffering from chronic viral hepatitis. Durign past 20 years, a series of neolignans have been isolated and identified as effective principles. Pharmacological studies revealed that they increased liver protein and glicogen synthesis, antagonized liver injuries from CCl4 and thioacetamide. The mechanism of SGPT lowering was considered as a hepato-protective and membrane stabilize action, although inhibition of the activity of liver GPT may also be existed. It was found that some principles of Schisandrae have an inducing effect on hepatic microsomal drug-metabolizing enzynme system P-450, thus explained their anti-toxic, anti-carcinogenic and anti-mutagenic effects. A synthetic derivative compound of Schisandrin called DDB has most of the above mentioned actions now used widely in Chine as a hepato-protective drug with high effectiveness in normalizing liver functions and very low side effects. From Schisandrin to synthesized DDB, pointed out a successful way in the development of new drugs from natural products. |
| first_indexed | 2024-03-12T18:04:56Z |
| format | Article |
| id | doaj.art-ec863c07ca9048759912bc89ff6bbe8b |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:04:56Z |
| publishDate | 1991-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-ec863c07ca9048759912bc89ff6bbe8b2023-08-02T09:32:14ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601991-01-0186313710.1590/S0074-02761991000600010Bioactivity of neolignans from fructus SchizandraeXiao-Yu LiFructus Schisandrae sinensis Baill, a traditional Chinese medicine, used as tonic and sedative, has been shown at the beginning of 70's to lower the elevated serum glutamic-pyruvic transaminase (SGPT) levels of patients suffering from chronic viral hepatitis. Durign past 20 years, a series of neolignans have been isolated and identified as effective principles. Pharmacological studies revealed that they increased liver protein and glicogen synthesis, antagonized liver injuries from CCl4 and thioacetamide. The mechanism of SGPT lowering was considered as a hepato-protective and membrane stabilize action, although inhibition of the activity of liver GPT may also be existed. It was found that some principles of Schisandrae have an inducing effect on hepatic microsomal drug-metabolizing enzynme system P-450, thus explained their anti-toxic, anti-carcinogenic and anti-mutagenic effects. A synthetic derivative compound of Schisandrin called DDB has most of the above mentioned actions now used widely in Chine as a hepato-protective drug with high effectiveness in normalizing liver functions and very low side effects. From Schisandrin to synthesized DDB, pointed out a successful way in the development of new drugs from natural products.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600010Fructus SchizandraeSchizandraceaedibenzocyclooctene neolignanshepatoprotective agentsDDB |
| spellingShingle | Xiao-Yu Li Bioactivity of neolignans from fructus Schizandrae Memorias do Instituto Oswaldo Cruz Fructus Schizandrae Schizandraceae dibenzocyclooctene neolignans hepatoprotective agents DDB |
| title | Bioactivity of neolignans from fructus Schizandrae |
| title_full | Bioactivity of neolignans from fructus Schizandrae |
| title_fullStr | Bioactivity of neolignans from fructus Schizandrae |
| title_full_unstemmed | Bioactivity of neolignans from fructus Schizandrae |
| title_short | Bioactivity of neolignans from fructus Schizandrae |
| title_sort | bioactivity of neolignans from fructus schizandrae |
| topic | Fructus Schizandrae Schizandraceae dibenzocyclooctene neolignans hepatoprotective agents DDB |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600010 |
| work_keys_str_mv | AT xiaoyuli bioactivityofneolignansfromfructusschizandrae |