Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics
Integrative analysis using omics-based technologies results in the identification of a large number of putative short open reading frames (sORFs) with protein-coding capacity within transcripts previously identified as long noncoding RNAs (lncRNAs) or transcripts of unknown function (TUFs). sORFs we...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Genetics |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fgene.2018.00144/full |
| _version_ | 1819074754081980416 |
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| author | Fouzia Yeasmin Tetsushi Yada Nobuyoshi Akimitsu |
| author_facet | Fouzia Yeasmin Tetsushi Yada Nobuyoshi Akimitsu |
| author_sort | Fouzia Yeasmin |
| collection | DOAJ |
| description | Integrative analysis using omics-based technologies results in the identification of a large number of putative short open reading frames (sORFs) with protein-coding capacity within transcripts previously identified as long noncoding RNAs (lncRNAs) or transcripts of unknown function (TUFs). sORFs were previously overlooked because of their diminutive size and the difficulty of identification by bioinformatics analyses. There is now growing evidence of the existence of potentially functional micropeptides produced from sORFs within cells of diverse species. Recent characterization of a few of these revealed their significant divergent roles in many fundamental biological processes, where some also show important relationships with pathogenesis. Recent works therefore provide new insights for exploring the wealth of information that may lie within sORF-encoded short proteins. Here, we summarize the current progress and view of micropeptides encoded in sORFs of protein-coding genes. |
| first_indexed | 2024-12-21T18:14:32Z |
| format | Article |
| id | doaj.art-ec8729d444134ad58e873401f4e63b80 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-21T18:14:32Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-ec8729d444134ad58e873401f4e63b802022-12-21T18:54:43ZengFrontiers Media S.A.Frontiers in Genetics1664-80212018-04-01910.3389/fgene.2018.00144354541Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and ProteomicsFouzia Yeasmin0Tetsushi Yada1Nobuyoshi Akimitsu2Isotope Science Centre, The University of Tokyo, Tokyo, JapanDepartment of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka, JapanIsotope Science Centre, The University of Tokyo, Tokyo, JapanIntegrative analysis using omics-based technologies results in the identification of a large number of putative short open reading frames (sORFs) with protein-coding capacity within transcripts previously identified as long noncoding RNAs (lncRNAs) or transcripts of unknown function (TUFs). sORFs were previously overlooked because of their diminutive size and the difficulty of identification by bioinformatics analyses. There is now growing evidence of the existence of potentially functional micropeptides produced from sORFs within cells of diverse species. Recent characterization of a few of these revealed their significant divergent roles in many fundamental biological processes, where some also show important relationships with pathogenesis. Recent works therefore provide new insights for exploring the wealth of information that may lie within sORF-encoded short proteins. Here, we summarize the current progress and view of micropeptides encoded in sORFs of protein-coding genes.http://journal.frontiersin.org/article/10.3389/fgene.2018.00144/fulllncRNAsTUFssORFsmicropeptidestranslation |
| spellingShingle | Fouzia Yeasmin Tetsushi Yada Nobuyoshi Akimitsu Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics Frontiers in Genetics lncRNAs TUFs sORFs micropeptides translation |
| title | Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics |
| title_full | Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics |
| title_fullStr | Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics |
| title_full_unstemmed | Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics |
| title_short | Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics |
| title_sort | micropeptides encoded in transcripts previously identified as long noncoding rnas a new chapter in transcriptomics and proteomics |
| topic | lncRNAs TUFs sORFs micropeptides translation |
| url | http://journal.frontiersin.org/article/10.3389/fgene.2018.00144/full |
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