Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking
Tobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma (ccRCC). TS alters the distribution and activities of cadmi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-03-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1859917 |
| _version_ | 1797677116193505280 |
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| author | Maria F. Czyzyk-Krzeska Jarek Meller Julio A. Landero Figueroa David R. Plas John T. Cunningham |
| author_facet | Maria F. Czyzyk-Krzeska Jarek Meller Julio A. Landero Figueroa David R. Plas John T. Cunningham |
| author_sort | Maria F. Czyzyk-Krzeska |
| collection | DOAJ |
| description | Tobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma (ccRCC). TS alters the distribution and activities of cadmium, arsenic and copper in a manner mechanistically supporting metabolic remodeling. Alterations in metabolism and metal distribution identify new actionable targets for treatment of ccRCC. |
| first_indexed | 2024-03-11T22:40:18Z |
| format | Article |
| id | doaj.art-ec88ba9d0f424b73a36d79f03d98bf58 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:18Z |
| publishDate | 2021-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-ec88ba9d0f424b73a36d79f03d98bf582023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-03-018210.1080/23723556.2020.18599171859917Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smokingMaria F. Czyzyk-Krzeska0Jarek Meller1Julio A. Landero Figueroa2David R. Plas3John T. Cunningham4University of CincinnatiUniversity of CincinnatiUniversity of CincinnatiUniversity of CincinnatiUniversity of CincinnatiTobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma (ccRCC). TS alters the distribution and activities of cadmium, arsenic and copper in a manner mechanistically supporting metabolic remodeling. Alterations in metabolism and metal distribution identify new actionable targets for treatment of ccRCC.http://dx.doi.org/10.1080/23723556.2020.1859917clear cell renal cell carcinomatobacco smokingoxidative phosphorylationarseniccopper |
| spellingShingle | Maria F. Czyzyk-Krzeska Jarek Meller Julio A. Landero Figueroa David R. Plas John T. Cunningham Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking Molecular & Cellular Oncology clear cell renal cell carcinoma tobacco smoking oxidative phosphorylation arsenic copper |
| title | Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking |
| title_full | Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking |
| title_fullStr | Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking |
| title_full_unstemmed | Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking |
| title_short | Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking |
| title_sort | metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking |
| topic | clear cell renal cell carcinoma tobacco smoking oxidative phosphorylation arsenic copper |
| url | http://dx.doi.org/10.1080/23723556.2020.1859917 |
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