On cytoadhesion of Plasmodium vivax: raison d'être?
It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-08-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010&lng=en&tlng=en |
| _version_ | 1797721311847383040 |
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| author | Fabio TM Costa Stefanie CP Lopes Mireia Ferrer Juliana A Leite Lorena Martin-Jaular Maria Bernabeu Paulo A Nogueira Maria Paula G Mourão Carmen Fernandez-Becerra Marcus VG Lacerda Hernando del Portillo |
| author_facet | Fabio TM Costa Stefanie CP Lopes Mireia Ferrer Juliana A Leite Lorena Martin-Jaular Maria Bernabeu Paulo A Nogueira Maria Paula G Mourão Carmen Fernandez-Becerra Marcus VG Lacerda Hernando del Portillo |
| author_sort | Fabio TM Costa |
| collection | DOAJ |
| description | It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite. |
| first_indexed | 2024-03-12T09:32:39Z |
| format | Article |
| id | doaj.art-ec8a4935c2564c3bb185da68c52d0085 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T09:32:39Z |
| publishDate | 2011-08-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-ec8a4935c2564c3bb185da68c52d00852023-09-02T13:54:03ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-08-01106suppl 1798410.1590/S0074-02762011000900010S0074-02762011000900010On cytoadhesion of Plasmodium vivax: raison d'être?Fabio TM Costa0Stefanie CP Lopes1Mireia Ferrer2Juliana A Leite3Lorena Martin-Jaular4Maria Bernabeu5Paulo A Nogueira6Maria Paula G Mourão7Carmen Fernandez-Becerra8Marcus VG Lacerda9Hernando del Portillo10Universidade Estadual de CampinasUniversidade Estadual de CampinasBarcelona Center for International Health ResearchUniversidade Estadual de CampinasBarcelona Center for International Health ResearchBarcelona Center for International Health ResearchFundação Oswaldo CruzFundação de Medicina Tropical Doutor Heitor Vieira DouradoBarcelona Center for International Health ResearchFundação de Medicina Tropical Doutor Heitor Vieira DouradoBarcelona Center for International Health ResearchIt is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010&lng=en&tlng=enPlasmodium vivaxmalariacytoadherencesevere disease |
| spellingShingle | Fabio TM Costa Stefanie CP Lopes Mireia Ferrer Juliana A Leite Lorena Martin-Jaular Maria Bernabeu Paulo A Nogueira Maria Paula G Mourão Carmen Fernandez-Becerra Marcus VG Lacerda Hernando del Portillo On cytoadhesion of Plasmodium vivax: raison d'être? Memorias do Instituto Oswaldo Cruz Plasmodium vivax malaria cytoadherence severe disease |
| title | On cytoadhesion of Plasmodium vivax: raison d'être? |
| title_full | On cytoadhesion of Plasmodium vivax: raison d'être? |
| title_fullStr | On cytoadhesion of Plasmodium vivax: raison d'être? |
| title_full_unstemmed | On cytoadhesion of Plasmodium vivax: raison d'être? |
| title_short | On cytoadhesion of Plasmodium vivax: raison d'être? |
| title_sort | on cytoadhesion of plasmodium vivax raison d etre |
| topic | Plasmodium vivax malaria cytoadherence severe disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010&lng=en&tlng=en |
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