Should ocular Demodex be checked and treated in refractory keratitis patients without blepharitis?
AIM: To evaluate the correlation between Demodex infestation and keratitis, and to assess demodicosis using a simple approach. METHODS: A modified slit lamp illumination (at 40× magnification) was used to observe Demodex tails in 40 patients with refractory keratitis and 80 healthy controls. Bacteri...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-02-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2023/2/20230205.pdf |
| _version_ | 1811173572899504128 |
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| author | Ying-Ying Gao Ting Wang Yu-Ting Jiang Ming-Jun Yang Xiu-Hai Lu Ling Zheng Shu-Ting Wang Wei-Yun Shi |
| author_facet | Ying-Ying Gao Ting Wang Yu-Ting Jiang Ming-Jun Yang Xiu-Hai Lu Ling Zheng Shu-Ting Wang Wei-Yun Shi |
| author_sort | Ying-Ying Gao |
| collection | DOAJ |
| description | AIM: To evaluate the correlation between Demodex infestation and keratitis, and to assess demodicosis using a simple approach. METHODS: A modified slit lamp illumination (at 40× magnification) was used to observe Demodex tails in 40 patients with refractory keratitis and 80 healthy controls. Bacterial smear and culture of the conjunctival sac and corneal lesion were performed to identify the pathogen. Tea tree oil ointment (TTOO) was added as a Demodex killing agent for lid scrubs to the treatment when Demodex infestation was confirmed. RESULTS: Demodex tails were found in all patients compared to 42/80 of the controls (P<0.01). Seventeen patients presented blepharitis, while 23 were free of scales and inflammation at the lid margin. The demodicosis was mild, moderate, and severe in 8, 19, and 13 patients, respectively, compared to mild in 42 controls (P<0.01). The keratitis was mild, moderate, and severe in 13, 19, and 8 patients, respectively. The severity of Demodex infestation was not correlated to the severity of keratitis (P=0.126). The growth of Staphylococcus was revealed in nine patients who did not react to antibiotic eye drops prior to the TTOO treatment. Patients' signs and symptoms got resolved after the lid scrub with TTOO. CONCLUSION: Ocular Demodex needs to be checked and treated in refractory keratitis patients with or without blepharitis. A slit-lamp illumination under high magnification favors the judgment of the severity of Demodex infestation. |
| first_indexed | 2024-04-10T17:49:12Z |
| format | Article |
| id | doaj.art-ec8d710dc9be49949add168780bf13a2 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-10T17:49:12Z |
| publishDate | 2023-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-ec8d710dc9be49949add168780bf13a22023-02-03T03:11:48ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982023-02-0116220120710.18240/ijo.2023.02.0520230205Should ocular Demodex be checked and treated in refractory keratitis patients without blepharitis?Ying-Ying Gao0Ting Wang1Yu-Ting Jiang2Ming-Jun Yang3Xiu-Hai Lu4Ling Zheng5Shu-Ting Wang6Wei-Yun Shi7Wei-Yun Shi. Eye Hospital of Shandong First Medical University, Jinan 250021, Shandong Province, China. weiyunshi@163.comEye Hospital of Shandong First Medical University, Jinan 250021, Shandong Province, China; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, ChinaDepartment of Ophthalmology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000, Fujian Province, ChinaDepartment of Ophthalmology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000, Fujian Province, ChinaEye Hospital of Shandong First Medical University, Jinan 250021, Shandong Province, ChinaDepartment of Ophthalmology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000, Fujian Province, ChinaEye Hospital of Shandong First Medical University, Jinan 250021, Shandong Province, ChinaEye Hospital of Shandong First Medical University, Jinan 250021, Shandong Province, China; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, Shandong Province, ChinaAIM: To evaluate the correlation between Demodex infestation and keratitis, and to assess demodicosis using a simple approach. METHODS: A modified slit lamp illumination (at 40× magnification) was used to observe Demodex tails in 40 patients with refractory keratitis and 80 healthy controls. Bacterial smear and culture of the conjunctival sac and corneal lesion were performed to identify the pathogen. Tea tree oil ointment (TTOO) was added as a Demodex killing agent for lid scrubs to the treatment when Demodex infestation was confirmed. RESULTS: Demodex tails were found in all patients compared to 42/80 of the controls (P<0.01). Seventeen patients presented blepharitis, while 23 were free of scales and inflammation at the lid margin. The demodicosis was mild, moderate, and severe in 8, 19, and 13 patients, respectively, compared to mild in 42 controls (P<0.01). The keratitis was mild, moderate, and severe in 13, 19, and 8 patients, respectively. The severity of Demodex infestation was not correlated to the severity of keratitis (P=0.126). The growth of Staphylococcus was revealed in nine patients who did not react to antibiotic eye drops prior to the TTOO treatment. Patients' signs and symptoms got resolved after the lid scrub with TTOO. CONCLUSION: Ocular Demodex needs to be checked and treated in refractory keratitis patients with or without blepharitis. A slit-lamp illumination under high magnification favors the judgment of the severity of Demodex infestation.http://ies.ijo.cn/en_publish/2023/2/20230205.pdfdemodexkeratitisblepharitisslit-lamp microscopy |
| spellingShingle | Ying-Ying Gao Ting Wang Yu-Ting Jiang Ming-Jun Yang Xiu-Hai Lu Ling Zheng Shu-Ting Wang Wei-Yun Shi Should ocular Demodex be checked and treated in refractory keratitis patients without blepharitis? International Journal of Ophthalmology demodex keratitis blepharitis slit-lamp microscopy |
| title | Should ocular Demodex be checked and treated in refractory keratitis patients without blepharitis? |
| title_full | Should ocular Demodex be checked and treated in refractory keratitis patients without blepharitis? |
| title_fullStr | Should ocular Demodex be checked and treated in refractory keratitis patients without blepharitis? |
| title_full_unstemmed | Should ocular Demodex be checked and treated in refractory keratitis patients without blepharitis? |
| title_short | Should ocular Demodex be checked and treated in refractory keratitis patients without blepharitis? |
| title_sort | should ocular demodex be checked and treated in refractory keratitis patients without blepharitis |
| topic | demodex keratitis blepharitis slit-lamp microscopy |
| url | http://ies.ijo.cn/en_publish/2023/2/20230205.pdf |
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