Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels. However, the role of stretch-activated ion channels (SACs) in arterial smooth muscle cells...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-11-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715011146 |
| _version_ | 1811333547502338048 |
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| author | Kevin Retailleau Fabrice Duprat Malika Arhatte Sanjeev Sumant Ranade Rémi Peyronnet Joana Raquel Martins Martine Jodar Céline Moro Stefan Offermanns Yuanyi Feng Sophie Demolombe Amanda Patel Eric Honoré |
| author_facet | Kevin Retailleau Fabrice Duprat Malika Arhatte Sanjeev Sumant Ranade Rémi Peyronnet Joana Raquel Martins Martine Jodar Céline Moro Stefan Offermanns Yuanyi Feng Sophie Demolombe Amanda Patel Eric Honoré |
| author_sort | Kevin Retailleau |
| collection | DOAJ |
| description | The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels. However, the role of stretch-activated ion channels (SACs) in arterial smooth muscle cells in the adult remains unknown. Here, we show that Piezo1 is highly expressed in myocytes of small-diameter arteries and that smooth-muscle-specific Piezo1 deletion fully impairs SAC activity. While Piezo1 is dispensable for the arterial myogenic tone, it is involved in the structural remodeling of small arteries. Increased Piezo1 opening has a trophic effect on resistance arteries, influencing both diameter and wall thickness in hypertension. Piezo1 mediates a rise in cytosolic calcium and stimulates activity of transglutaminases, cross-linking enzymes required for the remodeling of small arteries. In conclusion, we have established the connection between an early mechanosensitive process, involving Piezo1 in smooth muscle cells, and a clinically relevant arterial remodeling. |
| first_indexed | 2024-04-13T16:54:32Z |
| format | Article |
| id | doaj.art-ec8f3cfff1984d47aedd9a0673708453 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-13T16:54:32Z |
| publishDate | 2015-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-ec8f3cfff1984d47aedd9a06737084532022-12-22T02:38:51ZengElsevierCell Reports2211-12472015-11-011361161117110.1016/j.celrep.2015.09.072Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial RemodelingKevin Retailleau0Fabrice Duprat1Malika Arhatte2Sanjeev Sumant Ranade3Rémi Peyronnet4Joana Raquel Martins5Martine Jodar6Céline Moro7Stefan Offermanns8Yuanyi Feng9Sophie Demolombe10Amanda Patel11Eric Honoré12Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceDepartment of Molecular and Cellular Neuroscience, Howard Hughes Medical Institute, The Scripps Research Institute, La Jolla, CA 92037, USAInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceMax Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, GermanyDepartment of Neurology, Northwestern University, Chicago, IL 60611, USAInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, 06560 Valbonne, FranceThe mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels. However, the role of stretch-activated ion channels (SACs) in arterial smooth muscle cells in the adult remains unknown. Here, we show that Piezo1 is highly expressed in myocytes of small-diameter arteries and that smooth-muscle-specific Piezo1 deletion fully impairs SAC activity. While Piezo1 is dispensable for the arterial myogenic tone, it is involved in the structural remodeling of small arteries. Increased Piezo1 opening has a trophic effect on resistance arteries, influencing both diameter and wall thickness in hypertension. Piezo1 mediates a rise in cytosolic calcium and stimulates activity of transglutaminases, cross-linking enzymes required for the remodeling of small arteries. In conclusion, we have established the connection between an early mechanosensitive process, involving Piezo1 in smooth muscle cells, and a clinically relevant arterial remodeling.http://www.sciencedirect.com/science/article/pii/S2211124715011146 |
| spellingShingle | Kevin Retailleau Fabrice Duprat Malika Arhatte Sanjeev Sumant Ranade Rémi Peyronnet Joana Raquel Martins Martine Jodar Céline Moro Stefan Offermanns Yuanyi Feng Sophie Demolombe Amanda Patel Eric Honoré Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling Cell Reports |
| title | Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling |
| title_full | Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling |
| title_fullStr | Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling |
| title_full_unstemmed | Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling |
| title_short | Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling |
| title_sort | piezo1 in smooth muscle cells is involved in hypertension dependent arterial remodeling |
| url | http://www.sciencedirect.com/science/article/pii/S2211124715011146 |
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