Infection by <named-content content-type="genus-species">Anaplasma phagocytophilum</named-content> Requires Recruitment of Low-Density Lipoprotein Cholesterol by Flotillins

Infection by <named-content content-type="genus-species">Anaplasma phagocytophilum</named-content> Requires Recruitment of Low-Density Lipoprotein Cholesterol by Flotillins

ABSTRACT Anaplasma phagocytophilum is an obligatory intracellular bacterium that proliferates in membrane-bound inclusions. A. phagocytophilum is dependent on cholesterol and acquire cholesterol from low-density lipoprotein (LDL) endocytosed by mammalian host cells. The mechanism of cholesterol tran...

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Bibliographic Details
Main Authors: Qingming Xiong, Mingqun Lin, Weiyan Huang, Yasuko Rikihisa
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
Anaplasma phagocytophilum
cholesterol
flotillin-1
flotillin-2
LDL
acid lipase
Online Access:https://journals.asm.org/doi/10.1128/mBio.02783-18

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