Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination
Amid the ongoing Coronavirus Disease 2019 (COVID-19) pandemic, vaccination and early therapeutic interventions are the most effective means to combat and control the severity of the disease. Host immune responses to SARS-CoV-2 and its variants, particularly adaptive immune responses, should be fully...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.964976/full |
| _version_ | 1811187162598604800 |
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| author | Furong Qi Furong Qi Yingyin Cao Shuye Zhang Zheng Zhang Zheng Zhang Zheng Zhang |
| author_facet | Furong Qi Furong Qi Yingyin Cao Shuye Zhang Zheng Zhang Zheng Zhang Zheng Zhang |
| author_sort | Furong Qi |
| collection | DOAJ |
| description | Amid the ongoing Coronavirus Disease 2019 (COVID-19) pandemic, vaccination and early therapeutic interventions are the most effective means to combat and control the severity of the disease. Host immune responses to SARS-CoV-2 and its variants, particularly adaptive immune responses, should be fully understood to develop improved strategies to implement these measures. Single-cell multi-omic technologies, including flow cytometry, single-cell transcriptomics, and single-cell T-cell receptor (TCR) and B-cell receptor (BCR) profiling, offer a better solution to examine the protective or pathological immune responses and molecular mechanisms associated with SARS-CoV-2 infection, thus providing crucial support for the development of vaccines and therapeutics for COVID-19. Recent reviews have revealed the overall immune landscape of natural SARS-CoV-2 infection, and this review will focus on adaptive immune responses (including T cells and B cells) to SARS-CoV-2 revealed by single-cell multi-omics technologies. In addition, we explore how the single-cell analyses disclose the critical components of immune protection and pathogenesis during SARS-CoV-2 infection through the comparison between the adaptive immune responses induced by natural infection and by vaccination. |
| first_indexed | 2024-04-11T13:57:34Z |
| format | Article |
| id | doaj.art-ec92fe4b95bd417dbd2e5997297b38bb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T13:57:34Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec92fe4b95bd417dbd2e5997297b38bb2022-12-22T04:20:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.964976964976Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccinationFurong Qi0Furong Qi1Yingyin Cao2Shuye Zhang3Zheng Zhang4Zheng Zhang5Zheng Zhang6Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, ChinaShenzhen Key Laboratory of Single-Cell Omics Reasearch and Application, Shenzhen, ChinaInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, ChinaClinical Center for BioTherapy and Institutes of Biomedical Sciences, Zhongshan Hospital, Fudan University, Shanghai, ChinaInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, ChinaShenzhen Key Laboratory of Single-Cell Omics Reasearch and Application, Shenzhen, ChinaShenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science, Shenzhen, ChinaAmid the ongoing Coronavirus Disease 2019 (COVID-19) pandemic, vaccination and early therapeutic interventions are the most effective means to combat and control the severity of the disease. Host immune responses to SARS-CoV-2 and its variants, particularly adaptive immune responses, should be fully understood to develop improved strategies to implement these measures. Single-cell multi-omic technologies, including flow cytometry, single-cell transcriptomics, and single-cell T-cell receptor (TCR) and B-cell receptor (BCR) profiling, offer a better solution to examine the protective or pathological immune responses and molecular mechanisms associated with SARS-CoV-2 infection, thus providing crucial support for the development of vaccines and therapeutics for COVID-19. Recent reviews have revealed the overall immune landscape of natural SARS-CoV-2 infection, and this review will focus on adaptive immune responses (including T cells and B cells) to SARS-CoV-2 revealed by single-cell multi-omics technologies. In addition, we explore how the single-cell analyses disclose the critical components of immune protection and pathogenesis during SARS-CoV-2 infection through the comparison between the adaptive immune responses induced by natural infection and by vaccination.https://www.frontiersin.org/articles/10.3389/fimmu.2022.964976/fullSARS-CoV-2infectionvaccineadaptive immune responseantibody production |
| spellingShingle | Furong Qi Furong Qi Yingyin Cao Shuye Zhang Zheng Zhang Zheng Zhang Zheng Zhang Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination Frontiers in Immunology SARS-CoV-2 infection vaccine adaptive immune response antibody production |
| title | Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination |
| title_full | Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination |
| title_fullStr | Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination |
| title_full_unstemmed | Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination |
| title_short | Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination |
| title_sort | single cell analysis of the adaptive immune response to sars cov 2 infection and vaccination |
| topic | SARS-CoV-2 infection vaccine adaptive immune response antibody production |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.964976/full |
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