Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Study
Using valved holding chambers (VHC) during aerosol therapy has been reported to improve the inhaled dose with various aerosol devices, including vibrating mesh nebulizers. The aim of this study was to quantify the pulmonary deposition of a jet nebulizer (JN) with and without a VHC, and a mesh nebuli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/3/566 |
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| author | Luciana Alcoforado Dulciane Nunes Paiva Arzu Ari Jacqueline de Melo Barcelar Simone Cristina Soares Brandão James B. Fink Armele Dornelas de Andrade |
| author_facet | Luciana Alcoforado Dulciane Nunes Paiva Arzu Ari Jacqueline de Melo Barcelar Simone Cristina Soares Brandão James B. Fink Armele Dornelas de Andrade |
| author_sort | Luciana Alcoforado |
| collection | DOAJ |
| description | Using valved holding chambers (VHC) during aerosol therapy has been reported to improve the inhaled dose with various aerosol devices, including vibrating mesh nebulizers. The aim of this study was to quantify the pulmonary deposition of a jet nebulizer (JN) with and without a VHC, and a mesh nebulizer (MN) with a VHC in a randomized cross-over trial with seven healthy consenting adults. Our hypothesis was that the use of a VHC would improve deposition with the JN. Diethylnitriaminopentacetic acid with technetium (DTPA-Tc99m), with the activity of 1 mC with 0.9% saline solution was nebulized. The radiolabeled aerosol was detected by 2D planar scintigraphy after administration. The pulmonary deposition was greater with a JN with a VHC (4.5%) than a JN alone (3.2%; <i>p</i> = 0.005. However, an MN with a VHC (30.0%) was six-fold greater than a JN or JN with a VHC (<i>p</i> < 0.001). The extrapulmonary deposition was higher in the JN group without a VHC than in the other two modalities (<i>p</i> < 0.001). Deposition in the device was greater with a JN + VHC than an MN+/VHC (<i>p</i> < 0.001). Lower residual drug at the end of the dose was detected with an MN than either JN configuration. The exhaled dose was greater with a JN alone than either an MN or JN with VHC (<i>p</i> < 0.001). In conclusion, the addition of the VHC did not substantially improve the efficiency of aerosol lung deposition over a JN alone. |
| first_indexed | 2024-03-09T12:59:20Z |
| format | Article |
| id | doaj.art-ec9411e6396542418b76571bf5d44336 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:59:20Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-ec9411e6396542418b76571bf5d443362023-11-30T21:56:42ZengMDPI AGPharmaceutics1999-49232022-03-0114356610.3390/pharmaceutics14030566Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover StudyLuciana Alcoforado0Dulciane Nunes Paiva1Arzu Ari2Jacqueline de Melo Barcelar3Simone Cristina Soares Brandão4James B. Fink5Armele Dornelas de Andrade6Department of Physical Therapy, Universidade Federal de Pernambuco, Recife 50710-560, PE, BrazilDepartment of Physical Education and Health, Universidade de Santa Cruz do Sul, Santa Cruz do Sul 96815-010, RS, BrazilDepartment of Respiratory Therapy, Texas State University, Austin, TX 73301, USADepartment of Physical Therapy, Universidade Federal de Pernambuco, Recife 50710-560, PE, BrazilMedicine Nuclear Department, Universidade Federal de Pernambuco, Recife 50710-560, PE, BrazilDepartment of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University Medical Center, Chicago, IL 60007, USADepartment of Physical Therapy, Universidade Federal de Pernambuco, Recife 50710-560, PE, BrazilUsing valved holding chambers (VHC) during aerosol therapy has been reported to improve the inhaled dose with various aerosol devices, including vibrating mesh nebulizers. The aim of this study was to quantify the pulmonary deposition of a jet nebulizer (JN) with and without a VHC, and a mesh nebulizer (MN) with a VHC in a randomized cross-over trial with seven healthy consenting adults. Our hypothesis was that the use of a VHC would improve deposition with the JN. Diethylnitriaminopentacetic acid with technetium (DTPA-Tc99m), with the activity of 1 mC with 0.9% saline solution was nebulized. The radiolabeled aerosol was detected by 2D planar scintigraphy after administration. The pulmonary deposition was greater with a JN with a VHC (4.5%) than a JN alone (3.2%; <i>p</i> = 0.005. However, an MN with a VHC (30.0%) was six-fold greater than a JN or JN with a VHC (<i>p</i> < 0.001). The extrapulmonary deposition was higher in the JN group without a VHC than in the other two modalities (<i>p</i> < 0.001). Deposition in the device was greater with a JN + VHC than an MN+/VHC (<i>p</i> < 0.001). Lower residual drug at the end of the dose was detected with an MN than either JN configuration. The exhaled dose was greater with a JN alone than either an MN or JN with VHC (<i>p</i> < 0.001). In conclusion, the addition of the VHC did not substantially improve the efficiency of aerosol lung deposition over a JN alone.https://www.mdpi.com/1999-4923/14/3/566vibrating mesh nebulizerjet nebulizerscintigraphyspacervalved holding chamberaerosol delivery |
| spellingShingle | Luciana Alcoforado Dulciane Nunes Paiva Arzu Ari Jacqueline de Melo Barcelar Simone Cristina Soares Brandão James B. Fink Armele Dornelas de Andrade Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Study Pharmaceutics vibrating mesh nebulizer jet nebulizer scintigraphy spacer valved holding chamber aerosol delivery |
| title | Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Study |
| title_full | Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Study |
| title_fullStr | Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Study |
| title_full_unstemmed | Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Study |
| title_short | Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Study |
| title_sort | does valved holding chamber improve aerosol lung deposition with a jet nebulizer a randomized crossover study |
| topic | vibrating mesh nebulizer jet nebulizer scintigraphy spacer valved holding chamber aerosol delivery |
| url | https://www.mdpi.com/1999-4923/14/3/566 |
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