Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case report
Abstract Background Colorectal carcinoma with enteroblastic differentiation is a rare subtype of colorectal carcinomas expressing at least one characteristic immunohistochemical marker among α-fetoprotein, glypican-3, and spalt-like transcription factor 4. On the other hand, colorectal carcinoma wit...
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Format: | Article |
Language: | English |
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BMC
2022-11-01
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Series: | World Journal of Surgical Oncology |
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Online Access: | https://doi.org/10.1186/s12957-022-02838-1 |
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author | Takako Kihara Ryuichi Kuwahara Kurando Kusunoki Tomohiro Minagawa Yuki Horio Motoi Uchino Hiroki Ikeuchi Seiichi Hirota |
author_facet | Takako Kihara Ryuichi Kuwahara Kurando Kusunoki Tomohiro Minagawa Yuki Horio Motoi Uchino Hiroki Ikeuchi Seiichi Hirota |
author_sort | Takako Kihara |
collection | DOAJ |
description | Abstract Background Colorectal carcinoma with enteroblastic differentiation is a rare subtype of colorectal carcinomas expressing at least one characteristic immunohistochemical marker among α-fetoprotein, glypican-3, and spalt-like transcription factor 4. On the other hand, colorectal carcinoma with neuroendocrine differentiation is also a unique subtype of colorectal carcinomas showing expression of at least one distinctive marker among chromogranin A, synaptophysin, and CD56. Case presentation We experienced an extremely rare case of rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features in a 53-year-old male patient with long-standing ulcerative colitis (UC). Most of the tumor cells were positive for enteroblastic differentiation markers and approximately a half of them for neuroendocrine differentiation markers. Some tumor cells showed only enteroblastic differentiation, and some did only neuroendocrine feature, but some showed both enteroblastic and neuroendocrine differentiation. Conclusion Colorectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features has not been reported yet. Neoplastic transformation from pluripotent stem cells in dysplastic epithelium of long-standing UC patients may be associated with such dual differentiation features. |
first_indexed | 2024-04-12T06:29:47Z |
format | Article |
id | doaj.art-ec973456a0004d26844bbd7c49f4732e |
institution | Directory Open Access Journal |
issn | 1477-7819 |
language | English |
last_indexed | 2024-04-12T06:29:47Z |
publishDate | 2022-11-01 |
publisher | BMC |
record_format | Article |
series | World Journal of Surgical Oncology |
spelling | doaj.art-ec973456a0004d26844bbd7c49f4732e2022-12-22T03:44:03ZengBMCWorld Journal of Surgical Oncology1477-78192022-11-012011510.1186/s12957-022-02838-1Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case reportTakako Kihara0Ryuichi Kuwahara1Kurando Kusunoki2Tomohiro Minagawa3Yuki Horio4Motoi Uchino5Hiroki Ikeuchi6Seiichi Hirota7Department of Surgical Pathology, Hyogo Medical University HospitalDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University HospitalDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University HospitalDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University HospitalDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University HospitalDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University HospitalDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University HospitalDepartment of Surgical Pathology, Hyogo Medical University HospitalAbstract Background Colorectal carcinoma with enteroblastic differentiation is a rare subtype of colorectal carcinomas expressing at least one characteristic immunohistochemical marker among α-fetoprotein, glypican-3, and spalt-like transcription factor 4. On the other hand, colorectal carcinoma with neuroendocrine differentiation is also a unique subtype of colorectal carcinomas showing expression of at least one distinctive marker among chromogranin A, synaptophysin, and CD56. Case presentation We experienced an extremely rare case of rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features in a 53-year-old male patient with long-standing ulcerative colitis (UC). Most of the tumor cells were positive for enteroblastic differentiation markers and approximately a half of them for neuroendocrine differentiation markers. Some tumor cells showed only enteroblastic differentiation, and some did only neuroendocrine feature, but some showed both enteroblastic and neuroendocrine differentiation. Conclusion Colorectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features has not been reported yet. Neoplastic transformation from pluripotent stem cells in dysplastic epithelium of long-standing UC patients may be associated with such dual differentiation features.https://doi.org/10.1186/s12957-022-02838-1Colorectal carcinomaCarcinoma with enteroblastic differentiationCarcinoma with neuroendocrine differentiationUlcerative colitis |
spellingShingle | Takako Kihara Ryuichi Kuwahara Kurando Kusunoki Tomohiro Minagawa Yuki Horio Motoi Uchino Hiroki Ikeuchi Seiichi Hirota Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case report World Journal of Surgical Oncology Colorectal carcinoma Carcinoma with enteroblastic differentiation Carcinoma with neuroendocrine differentiation Ulcerative colitis |
title | Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case report |
title_full | Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case report |
title_fullStr | Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case report |
title_full_unstemmed | Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case report |
title_short | Rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis: a case report |
title_sort | rectal carcinoma with dual differentiation toward enteroblastic and neuroendocrine features arising in a patient with ulcerative colitis a case report |
topic | Colorectal carcinoma Carcinoma with enteroblastic differentiation Carcinoma with neuroendocrine differentiation Ulcerative colitis |
url | https://doi.org/10.1186/s12957-022-02838-1 |
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