Phenoxypropylamines: Synthesis and Antiulcer Evaluation
We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, 1H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2009-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/5/1818/ |
| _version_ | 1828950142554734592 |
|---|---|
| author | Dong-Mei Zhao Jia-Mei Wang Qian-Yun Zhang Bao-Yan Zhang Hui Zhang |
| author_facet | Dong-Mei Zhao Jia-Mei Wang Qian-Yun Zhang Bao-Yan Zhang Hui Zhang |
| author_sort | Dong-Mei Zhao |
| collection | DOAJ |
| description | We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, 1H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of themshowed significant gastric acid antisecretory activity. |
| first_indexed | 2024-12-14T06:18:37Z |
| format | Article |
| id | doaj.art-ec97cfaff3564306992b8dfa03313a5e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T06:18:37Z |
| publishDate | 2009-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ec97cfaff3564306992b8dfa03313a5e2022-12-21T23:13:56ZengMDPI AGMolecules1420-30492009-05-011451818182410.3390/molecules14051818Phenoxypropylamines: Synthesis and Antiulcer EvaluationDong-Mei ZhaoJia-Mei WangQian-Yun ZhangBao-Yan ZhangHui ZhangWe have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, 1H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of themshowed significant gastric acid antisecretory activity.http://www.mdpi.com/1420-3049/14/5/1818/roxatidinesynthesisantiulcer agentsphenoxypropylaminebiological activity |
| spellingShingle | Dong-Mei Zhao Jia-Mei Wang Qian-Yun Zhang Bao-Yan Zhang Hui Zhang Phenoxypropylamines: Synthesis and Antiulcer Evaluation Molecules roxatidine synthesis antiulcer agents phenoxypropylamine biological activity |
| title | Phenoxypropylamines: Synthesis and Antiulcer Evaluation |
| title_full | Phenoxypropylamines: Synthesis and Antiulcer Evaluation |
| title_fullStr | Phenoxypropylamines: Synthesis and Antiulcer Evaluation |
| title_full_unstemmed | Phenoxypropylamines: Synthesis and Antiulcer Evaluation |
| title_short | Phenoxypropylamines: Synthesis and Antiulcer Evaluation |
| title_sort | phenoxypropylamines synthesis and antiulcer evaluation |
| topic | roxatidine synthesis antiulcer agents phenoxypropylamine biological activity |
| url | http://www.mdpi.com/1420-3049/14/5/1818/ |
| work_keys_str_mv | AT dongmeizhao phenoxypropylaminessynthesisandantiulcerevaluation AT jiameiwang phenoxypropylaminessynthesisandantiulcerevaluation AT qianyunzhang phenoxypropylaminessynthesisandantiulcerevaluation AT baoyanzhang phenoxypropylaminessynthesisandantiulcerevaluation AT huizhang phenoxypropylaminessynthesisandantiulcerevaluation |