Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation
Stem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem cell mobilization. This review describes the i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060519876138 |
| _version_ | 1819030577284644864 |
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| author | Zejia Sun Xin Li Xiang Zheng Peng Cao Baozhong Yu Wei Wang |
| author_facet | Zejia Sun Xin Li Xiang Zheng Peng Cao Baozhong Yu Wei Wang |
| author_sort | Zejia Sun |
| collection | DOAJ |
| description | Stem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem cell mobilization. This review describes the important role of SDF-1 in tissue injury and how it works in tissue revascularization and regeneration via CXCR4. Furthermore, factors influencing the SDF-1/CXCR4 axis and its clinical potential in ischaemia reperfusion injury, such as renal transplantation, are discussed. Exploring signalling pathways of the SDF-1/CXCR4 axis will contribute to the development of stem cell therapy so that more clinical problems can be solved. Controlling directional homing of stem cells through the SDF-1/CXCR4 axis is key to improving the efficacy of stem cell therapy for tissue injury. CXCR4 antagonists may also be effective in increasing circulating levels of adult stem cells, thereby exerting beneficial effects on damaged or inflamed tissues in diseases that are currently not treated by standard approaches. |
| first_indexed | 2024-12-21T06:32:22Z |
| format | Article |
| id | doaj.art-ec984b6958db4023a31b3307d1449a22 |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-21T06:32:22Z |
| publishDate | 2019-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-ec984b6958db4023a31b3307d1449a222022-12-21T19:12:59ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002019-11-014710.1177/0300060519876138Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantationZejia SunXin LiXiang ZhengPeng CaoBaozhong YuWei WangStem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem cell mobilization. This review describes the important role of SDF-1 in tissue injury and how it works in tissue revascularization and regeneration via CXCR4. Furthermore, factors influencing the SDF-1/CXCR4 axis and its clinical potential in ischaemia reperfusion injury, such as renal transplantation, are discussed. Exploring signalling pathways of the SDF-1/CXCR4 axis will contribute to the development of stem cell therapy so that more clinical problems can be solved. Controlling directional homing of stem cells through the SDF-1/CXCR4 axis is key to improving the efficacy of stem cell therapy for tissue injury. CXCR4 antagonists may also be effective in increasing circulating levels of adult stem cells, thereby exerting beneficial effects on damaged or inflamed tissues in diseases that are currently not treated by standard approaches.https://doi.org/10.1177/0300060519876138 |
| spellingShingle | Zejia Sun Xin Li Xiang Zheng Peng Cao Baozhong Yu Wei Wang Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation Journal of International Medical Research |
| title | Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation |
| title_full | Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation |
| title_fullStr | Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation |
| title_full_unstemmed | Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation |
| title_short | Stromal cell-derived factor-1/CXC chemokine receptor 4 axis in injury repair and renal transplantation |
| title_sort | stromal cell derived factor 1 cxc chemokine receptor 4 axis in injury repair and renal transplantation |
| url | https://doi.org/10.1177/0300060519876138 |
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