Effects of Ingesting Fucoidan Derived from <i>Cladosiphon okamuranus</i> Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study
The aim of this study was to evaluate the effects of ingesting fucoidan derived from Okinawa mozuku (<i>Cladosiphon okamuranus</i>) on natural killer (NK) cell activity and to assess its safety in healthy adults via a randomized, double-blind, parallel-group, placebo-controlled pilot stu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/19/6/340 |
| _version_ | 1797530086600081408 |
|---|---|
| author | Makoto Tomori Takeaki Nagamine Tomofumi Miyamoto Masahiko Iha |
| author_facet | Makoto Tomori Takeaki Nagamine Tomofumi Miyamoto Masahiko Iha |
| author_sort | Makoto Tomori |
| collection | DOAJ |
| description | The aim of this study was to evaluate the effects of ingesting fucoidan derived from Okinawa mozuku (<i>Cladosiphon okamuranus</i>) on natural killer (NK) cell activity and to assess its safety in healthy adults via a randomized, double-blind, parallel-group, placebo-controlled pilot study. Subjects were randomly divided into two groups—a placebo group (ingesting citric acid, sucralose, and caramel beverages; <i>n</i> = 20; 45.5 ± 7.8 years (mean ± standard deviation)) and a fucoidan group (3.0 g/day from beverages; <i>n</i> = 20; 47.0 ± 7.6 years); after 12 weeks, blood, biochemical, and immunological tests were performed. Clinically adverse events were not observed in any of the tests during the study period. In addition, adverse events due to the test food were not observed. In the immunological tests, NK cell activity was significantly enhanced at 8 weeks in the fucoidan group, compared to before ingestion (0 weeks). In addition, a significantly enhanced NK cell activity was observed in male subjects at 8 weeks, compared with the placebo group. These results confirm that Okinawa mozuku-derived fucoidan enhances NK cell activity and suggest that it is a safe food material. |
| first_indexed | 2024-03-10T10:23:57Z |
| format | Article |
| id | doaj.art-ec9859ed0096456b8081eb4ef8168e7b |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T10:23:57Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ec9859ed0096456b8081eb4ef8168e7b2023-11-22T00:14:41ZengMDPI AGMarine Drugs1660-33972021-06-0119634010.3390/md19060340Effects of Ingesting Fucoidan Derived from <i>Cladosiphon okamuranus</i> Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot StudyMakoto Tomori0Takeaki Nagamine1Tomofumi Miyamoto2Masahiko Iha3South Product Co., Ltd., Okinawa 904-2311, JapanDepartment of Nutrition, Takasaki University of Health and Welfare, Gunma 370-0036, JapanDepartment of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, JapanSouth Product Co., Ltd., Okinawa 904-2311, JapanThe aim of this study was to evaluate the effects of ingesting fucoidan derived from Okinawa mozuku (<i>Cladosiphon okamuranus</i>) on natural killer (NK) cell activity and to assess its safety in healthy adults via a randomized, double-blind, parallel-group, placebo-controlled pilot study. Subjects were randomly divided into two groups—a placebo group (ingesting citric acid, sucralose, and caramel beverages; <i>n</i> = 20; 45.5 ± 7.8 years (mean ± standard deviation)) and a fucoidan group (3.0 g/day from beverages; <i>n</i> = 20; 47.0 ± 7.6 years); after 12 weeks, blood, biochemical, and immunological tests were performed. Clinically adverse events were not observed in any of the tests during the study period. In addition, adverse events due to the test food were not observed. In the immunological tests, NK cell activity was significantly enhanced at 8 weeks in the fucoidan group, compared to before ingestion (0 weeks). In addition, a significantly enhanced NK cell activity was observed in male subjects at 8 weeks, compared with the placebo group. These results confirm that Okinawa mozuku-derived fucoidan enhances NK cell activity and suggest that it is a safe food material.https://www.mdpi.com/1660-3397/19/6/340fucoidan<i>Cladosiphon okamuranus</i>Okinawa mozukuclinical studyNK cell activityimmunomodulatory |
| spellingShingle | Makoto Tomori Takeaki Nagamine Tomofumi Miyamoto Masahiko Iha Effects of Ingesting Fucoidan Derived from <i>Cladosiphon okamuranus</i> Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study Marine Drugs fucoidan <i>Cladosiphon okamuranus</i> Okinawa mozuku clinical study NK cell activity immunomodulatory |
| title | Effects of Ingesting Fucoidan Derived from <i>Cladosiphon okamuranus</i> Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study |
| title_full | Effects of Ingesting Fucoidan Derived from <i>Cladosiphon okamuranus</i> Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study |
| title_fullStr | Effects of Ingesting Fucoidan Derived from <i>Cladosiphon okamuranus</i> Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study |
| title_full_unstemmed | Effects of Ingesting Fucoidan Derived from <i>Cladosiphon okamuranus</i> Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study |
| title_short | Effects of Ingesting Fucoidan Derived from <i>Cladosiphon okamuranus</i> Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study |
| title_sort | effects of ingesting fucoidan derived from i cladosiphon okamuranus i tokida on human nk cells a randomized double blind parallel group placebo controlled pilot study |
| topic | fucoidan <i>Cladosiphon okamuranus</i> Okinawa mozuku clinical study NK cell activity immunomodulatory |
| url | https://www.mdpi.com/1660-3397/19/6/340 |
| work_keys_str_mv | AT makototomori effectsofingestingfucoidanderivedfromicladosiphonokamuranusitokidaonhumannkcellsarandomizeddoubleblindparallelgroupplacebocontrolledpilotstudy AT takeakinagamine effectsofingestingfucoidanderivedfromicladosiphonokamuranusitokidaonhumannkcellsarandomizeddoubleblindparallelgroupplacebocontrolledpilotstudy AT tomofumimiyamoto effectsofingestingfucoidanderivedfromicladosiphonokamuranusitokidaonhumannkcellsarandomizeddoubleblindparallelgroupplacebocontrolledpilotstudy AT masahikoiha effectsofingestingfucoidanderivedfromicladosiphonokamuranusitokidaonhumannkcellsarandomizeddoubleblindparallelgroupplacebocontrolledpilotstudy |