A Novel Co-Culture Model Reveals Enhanced CFTR Rescue in Primary Cystic Fibrosis Airway Epithelial Cultures with Persistent <i>Pseudomonas aeruginosa</i> Infection

A Novel Co-Culture Model Reveals Enhanced CFTR Rescue in Primary Cystic Fibrosis Airway Epithelial Cultures with Persistent <i>Pseudomonas aeruginosa</i> Infection

People with cystic fibrosis (pwCF) suffer from chronic and recurring bacterial lung infections that begin very early in life and contribute to progressive lung failure. CF is caused by mutations in the CF transmembrane conductance regulator (<i>CFTR</i>) gene, which encodes an ion channe...

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Bibliographic Details
Main Authors: Deborah M. Cholon, Matthew A. Greenwald, Matthew G. Higgs, Nancy L. Quinney, Susan E. Boyles, Suzanne L. Meinig, John T. Minges, Ashlesha Chaubal, Robert Tarran, Carla M. P. Ribeiro, Matthew C. Wolfgang, Martina Gentzsch
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
CFTR
cystic fibrosis
airway epithelia
<i>Pseudomonas aeruginosa</i>
cytokines
CFTR modulators
Online Access:https://www.mdpi.com/2073-4409/12/22/2618

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