Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction
Chemoradiotherapy and autoimmune disorder often lead to secondary thrombocytopenia in cancer patients, and thus, platelet transfusion is needed to stop or prevent bleeding. However, the effect of platelet transfusion remains controversial for the lack of agreement on transfusion strategies. Before b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523321000140 |
| _version_ | 1819116379988557824 |
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| author | Juan Wang Pan Zhou Yunwei Han Hongwei Zhang |
| author_facet | Juan Wang Pan Zhou Yunwei Han Hongwei Zhang |
| author_sort | Juan Wang |
| collection | DOAJ |
| description | Chemoradiotherapy and autoimmune disorder often lead to secondary thrombocytopenia in cancer patients, and thus, platelet transfusion is needed to stop or prevent bleeding. However, the effect of platelet transfusion remains controversial for the lack of agreement on transfusion strategies. Before being transfused, platelets are stored in blood banks, and their activation is usually stimulated. Increasing evidence shows activated platelets may promote metastasis and the proliferation of cancer cells, while cancer cells also induce platelet activation. Such a vicious cycle of interaction between activated platelets and cancer cells is harmful for the prognosis of cancer patients, which results in an increased tumor recurrence rate and decreased five-year survival rate. Therefore, it is important to explore platelet transfusion strategies, summarize mechanisms of interaction between platelets and tumor cells, and carefully evaluate the pros and cons of platelet transfusion for better treatment and prognosis for patients with cancer with secondary thrombocytopenia. |
| first_indexed | 2024-12-22T05:16:10Z |
| format | Article |
| id | doaj.art-ec990265227c46f6b2c963035d42a689 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-22T05:16:10Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-ec990265227c46f6b2c963035d42a6892022-12-21T18:37:51ZengElsevierTranslational Oncology1936-52332021-04-01144101022Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interactionJuan Wang0Pan Zhou1Yunwei Han2Hongwei Zhang3Class 2016 Clinical Medicine, Southwest Medical University, Luzhou 646000, Sichuan, ChinaDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, ChinaDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China; Corresponding authors.Department of Blood Transfusion, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China; Corresponding authors.Chemoradiotherapy and autoimmune disorder often lead to secondary thrombocytopenia in cancer patients, and thus, platelet transfusion is needed to stop or prevent bleeding. However, the effect of platelet transfusion remains controversial for the lack of agreement on transfusion strategies. Before being transfused, platelets are stored in blood banks, and their activation is usually stimulated. Increasing evidence shows activated platelets may promote metastasis and the proliferation of cancer cells, while cancer cells also induce platelet activation. Such a vicious cycle of interaction between activated platelets and cancer cells is harmful for the prognosis of cancer patients, which results in an increased tumor recurrence rate and decreased five-year survival rate. Therefore, it is important to explore platelet transfusion strategies, summarize mechanisms of interaction between platelets and tumor cells, and carefully evaluate the pros and cons of platelet transfusion for better treatment and prognosis for patients with cancer with secondary thrombocytopenia.http://www.sciencedirect.com/science/article/pii/S1936523321000140PlateletsCancer secondary thrombocytopeniaBlood transfusionCancer cells |
| spellingShingle | Juan Wang Pan Zhou Yunwei Han Hongwei Zhang Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction Translational Oncology Platelets Cancer secondary thrombocytopenia Blood transfusion Cancer cells |
| title | Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction |
| title_full | Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction |
| title_fullStr | Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction |
| title_full_unstemmed | Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction |
| title_short | Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction |
| title_sort | platelet transfusion for cancer secondary thrombocytopenia platelet and cancer cell interaction |
| topic | Platelets Cancer secondary thrombocytopenia Blood transfusion Cancer cells |
| url | http://www.sciencedirect.com/science/article/pii/S1936523321000140 |
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