MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy.
Resistance to glucocorticosteroids (GCs) is a major adverse prognostic factor in B-ALL, but the molecular mechanisms leading to GC resistance are not completely understood. Herein, we sought to elucidate the molecular background of GC resistance in B-ALL and characterize the therapeutic potential of...
Main Authors: | Anna Polak, Przemysław Kiliszek, Tomasz Sewastianik, Maciej Szydłowski, Ewa Jabłońska, Emilia Białopiotrowicz, Patryk Górniak, Sergiusz Markowicz, Eliza Nowak, Monika A Grygorowicz, Monika Prochorec-Sobieszek, Dominika Nowis, Jakub Gołąb, Sebastian Giebel, Ewa Lech-Marańda, Krzysztof Warzocha, Przemysław Juszczyński |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4872998?pdf=render |
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