Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence
Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/20/11237 |
| _version_ | 1797514348526043136 |
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| author | Chong-Sun Khoi Jia-Huang Chen Tzu-Yu Lin Chih-Kang Chiang Kuan-Yu Hung |
| author_facet | Chong-Sun Khoi Jia-Huang Chen Tzu-Yu Lin Chih-Kang Chiang Kuan-Yu Hung |
| author_sort | Chong-Sun Khoi |
| collection | DOAJ |
| description | Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity. |
| first_indexed | 2024-03-10T06:30:18Z |
| format | Article |
| id | doaj.art-ec9a05ffe7cc411183c0461fd10455c0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:30:18Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ec9a05ffe7cc411183c0461fd10455c02023-11-22T18:36:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122201123710.3390/ijms222011237Ochratoxin A-Induced Nephrotoxicity: Up-to-Date EvidenceChong-Sun Khoi0Jia-Huang Chen1Tzu-Yu Lin2Chih-Kang Chiang3Kuan-Yu Hung4Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 106, TaiwanGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 106, TaiwanDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, TaiwanGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 106, TaiwanDepartment of Internal Medicine, College of Medicine and Hospital, National Taiwan University, Taipei 106, TaiwanOchratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.https://www.mdpi.com/1422-0067/22/20/11237ochratoxin Anephrotoxicitymolecular interactionprevention |
| spellingShingle | Chong-Sun Khoi Jia-Huang Chen Tzu-Yu Lin Chih-Kang Chiang Kuan-Yu Hung Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence International Journal of Molecular Sciences ochratoxin A nephrotoxicity molecular interaction prevention |
| title | Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence |
| title_full | Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence |
| title_fullStr | Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence |
| title_full_unstemmed | Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence |
| title_short | Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence |
| title_sort | ochratoxin a induced nephrotoxicity up to date evidence |
| topic | ochratoxin A nephrotoxicity molecular interaction prevention |
| url | https://www.mdpi.com/1422-0067/22/20/11237 |
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