Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based study
<p>Abstract</p> <p>Background</p> <p>One of the main uses of seroprevalence studies it to evaluate vaccination programmes. In 1998, a programme of universal vaccination of preadolescents in schools with the hepatitis A vaccine was begun in Catalonia. The objective of th...
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| Format: | Article |
| Language: | English |
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BMC
2007-07-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/7/73 |
| _version_ | 1811246725290000384 |
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| author | Costa Josep Espuñes Jordi Plans Pere Bruguera Miquel Domínguez Àngela Plasencia Antoni Salleras Lluis |
| author_facet | Costa Josep Espuñes Jordi Plans Pere Bruguera Miquel Domínguez Àngela Plasencia Antoni Salleras Lluis |
| author_sort | Costa Josep |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>One of the main uses of seroprevalence studies it to evaluate vaccination programmes. In 1998, a programme of universal vaccination of preadolescents in schools with the hepatitis A vaccine was begun in Catalonia. The objective of this study was to investigate the prevalence and risk factors of hepatitis A virus infection (HAV) in a sample of the adult population of Catalonia in 2002 and to evaluate the changes with respect to a survey carried out in 1996.</p> <p>Methods</p> <p>The prevalence of HAV antibodies was determined by a third generation competitive immunometric assay in a representative sample of 1292 people aged >15 years. The association between the prevalence and different sociodemographic variables was determined by multiple logistic regression analysis.</p> <p>Results</p> <p>The standardized global prevalence of HAV antibodies in 2002 was 68.2%, increased with age (p < 0.0001) and was associated with being born outside Catalonia (OR: 1.75; 95% CI 1.11–2.76) and lower social class (OR: 1.14; 95% CI 1.05–1.25). Compared with the last survey carried out in 1996 the standardized global prevalence was lower (68.2% vs 77.8%; p < 0.0001) as was the prevalence in people under 45 years.</p> <p>Conclusion</p> <p>The prevalence of the hepatitis A virus is decreasing in the adult population of Catalonia, especially in the younger age groups. The programme of vaccination of adolescents begun in 1998 to control the disease can provide indirect protection to the unvaccinated population.</p> |
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| format | Article |
| id | doaj.art-ec9b80e6dbd443568a9987e5a914d6de |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T14:57:33Z |
| publishDate | 2007-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-ec9b80e6dbd443568a9987e5a914d6de2022-12-22T03:28:11ZengBMCBMC Infectious Diseases1471-23342007-07-01717310.1186/1471-2334-7-73Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based studyCosta JosepEspuñes JordiPlans PereBruguera MiquelDomínguez ÀngelaPlasencia AntoniSalleras Lluis<p>Abstract</p> <p>Background</p> <p>One of the main uses of seroprevalence studies it to evaluate vaccination programmes. In 1998, a programme of universal vaccination of preadolescents in schools with the hepatitis A vaccine was begun in Catalonia. The objective of this study was to investigate the prevalence and risk factors of hepatitis A virus infection (HAV) in a sample of the adult population of Catalonia in 2002 and to evaluate the changes with respect to a survey carried out in 1996.</p> <p>Methods</p> <p>The prevalence of HAV antibodies was determined by a third generation competitive immunometric assay in a representative sample of 1292 people aged >15 years. The association between the prevalence and different sociodemographic variables was determined by multiple logistic regression analysis.</p> <p>Results</p> <p>The standardized global prevalence of HAV antibodies in 2002 was 68.2%, increased with age (p < 0.0001) and was associated with being born outside Catalonia (OR: 1.75; 95% CI 1.11–2.76) and lower social class (OR: 1.14; 95% CI 1.05–1.25). Compared with the last survey carried out in 1996 the standardized global prevalence was lower (68.2% vs 77.8%; p < 0.0001) as was the prevalence in people under 45 years.</p> <p>Conclusion</p> <p>The prevalence of the hepatitis A virus is decreasing in the adult population of Catalonia, especially in the younger age groups. The programme of vaccination of adolescents begun in 1998 to control the disease can provide indirect protection to the unvaccinated population.</p>http://www.biomedcentral.com/1471-2334/7/73 |
| spellingShingle | Costa Josep Espuñes Jordi Plans Pere Bruguera Miquel Domínguez Àngela Plasencia Antoni Salleras Lluis Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based study BMC Infectious Diseases |
| title | Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based study |
| title_full | Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based study |
| title_fullStr | Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based study |
| title_full_unstemmed | Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based study |
| title_short | Declining hepatitis A seroprevalence in adults in Catalonia (Spain): a population-based study |
| title_sort | declining hepatitis a seroprevalence in adults in catalonia spain a population based study |
| url | http://www.biomedcentral.com/1471-2334/7/73 |
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