Cancer-Related Mutations in the Sam Domains of EphA2 Receptor and Ship2 Lipid Phosphatase: A Computational Study

Cancer-Related Mutations in the Sam Domains of EphA2 Receptor and Ship2 Lipid Phosphatase: A Computational Study

The lipid phosphatase Ship2 interacts with the EphA2 receptor by forming a heterotypic Sam (sterile alpha motif)–Sam complex. Ship2 works as a negative regulator of receptor endocytosis and consequent degradation, and anti-oncogenic effects in cancer cells should be induced by hindering its associat...

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Bibliographic Details
Main Authors: Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
Sam domain
EphA2
Ship2
Mid Loop (ML)
End Helix (EH)
AlphaFold2
Online Access:https://www.mdpi.com/1420-3049/29/5/1024

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