Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study
Abstract Background We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC). Methods A large-scale retrospective cohort study of all patients in Ontario diagnosed with squamous cancer of the larynx,...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40463-018-0322-7 |
| _version_ | 1797968104915992576 |
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| author | Alexandra E. Quimby Nicole L. Lebo Rebecca Griffiths Stephen Hall Jim Dimitroulakos Stephanie Johnson-Obaseki |
| author_facet | Alexandra E. Quimby Nicole L. Lebo Rebecca Griffiths Stephen Hall Jim Dimitroulakos Stephanie Johnson-Obaseki |
| author_sort | Alexandra E. Quimby |
| collection | DOAJ |
| description | Abstract Background We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC). Methods A large-scale retrospective cohort study of all patients in Ontario diagnosed with squamous cancer of the larynx, hypopharynx, and nasopharynx between Dec 1st 2007 to Dec 1st 2012 was undertaken. The Institute for Clinical and Evaluative Sciences was accessed to obtain patient demographic, treatment and outcome information. We included patients on metformin at the time of diagnosis. Kaplan Meier methods and Cox Regression models were used. Results Patients taking metformin at the time of diagnosis had a higher comorbid status but were otherwise similar to patients without metformin usage. Using multivariate analysis, neither overall survival nor disease specific survival was improved in patients on metformin (OS: HR 1.123, p = .338; DSS: HR 1.048, p = .792). Conclusions No survival advantage was observed in patients with HNSCC taking metformin at the time of diagnosis. |
| first_indexed | 2024-04-11T02:41:39Z |
| format | Article |
| id | doaj.art-ec9dab7eaefb4db2b8e43ba2958734f7 |
| institution | Directory Open Access Journal |
| issn | 1916-0216 |
| language | English |
| last_indexed | 2024-04-11T02:41:39Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj.art-ec9dab7eaefb4db2b8e43ba2958734f72023-01-02T19:05:09ZengBMCJournal of Otolaryngology - Head and Neck Surgery1916-02162018-12-014711910.1186/s40463-018-0322-7Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based studyAlexandra E. Quimby0Nicole L. Lebo1Rebecca Griffiths2Stephen Hall3Jim Dimitroulakos4Stephanie Johnson-Obaseki5Department of Otolaryngology, Head and Neck Surgery, University of OttawaDepartment of Otolaryngology, Head and Neck Surgery, University of OttawaInstitute for Clinical and Evaluative Sciences, Queen’s UniversityDepartment of Otolaryngology, Head and Neck Surgery, Queen’s UniversityOttawa Hospital Research InstituteDepartment of Otolaryngology, Head and Neck Surgery, University of OttawaAbstract Background We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC). Methods A large-scale retrospective cohort study of all patients in Ontario diagnosed with squamous cancer of the larynx, hypopharynx, and nasopharynx between Dec 1st 2007 to Dec 1st 2012 was undertaken. The Institute for Clinical and Evaluative Sciences was accessed to obtain patient demographic, treatment and outcome information. We included patients on metformin at the time of diagnosis. Kaplan Meier methods and Cox Regression models were used. Results Patients taking metformin at the time of diagnosis had a higher comorbid status but were otherwise similar to patients without metformin usage. Using multivariate analysis, neither overall survival nor disease specific survival was improved in patients on metformin (OS: HR 1.123, p = .338; DSS: HR 1.048, p = .792). Conclusions No survival advantage was observed in patients with HNSCC taking metformin at the time of diagnosis.http://link.springer.com/article/10.1186/s40463-018-0322-7Squamous cell carcinomaMetforminLarynxHypopharynxNasopharynx |
| spellingShingle | Alexandra E. Quimby Nicole L. Lebo Rebecca Griffiths Stephen Hall Jim Dimitroulakos Stephanie Johnson-Obaseki Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study Journal of Otolaryngology - Head and Neck Surgery Squamous cell carcinoma Metformin Larynx Hypopharynx Nasopharynx |
| title | Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study |
| title_full | Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study |
| title_fullStr | Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study |
| title_full_unstemmed | Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study |
| title_short | Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study |
| title_sort | does metformin usage improve survival in head and neck squamous cell carcinoma a population based study |
| topic | Squamous cell carcinoma Metformin Larynx Hypopharynx Nasopharynx |
| url | http://link.springer.com/article/10.1186/s40463-018-0322-7 |
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