Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from Molecular Imaging Studies
Chronic stress accounts for billions of dollars of economic loss annually in the United States alone, and is recognized as a major source of disability and mortality worldwide. Robust evidence suggests that chronic stress plays a significant role in the onset of severe and impairing psychiatric cond...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-06-01
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| Series: | Chronic Stress |
| Online Access: | https://doi.org/10.1177/2470547017710916 |
| _version_ | 1831764688060284928 |
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| author | Margaret T. Davis Sophie E. Holmes Robert H. Pietrzak Irina Esterlis |
| author_facet | Margaret T. Davis Sophie E. Holmes Robert H. Pietrzak Irina Esterlis |
| author_sort | Margaret T. Davis |
| collection | DOAJ |
| description | Chronic stress accounts for billions of dollars of economic loss annually in the United States alone, and is recognized as a major source of disability and mortality worldwide. Robust evidence suggests that chronic stress plays a significant role in the onset of severe and impairing psychiatric conditions, including major depressive disorder, bipolar disorder, and posttraumatic stress disorder. Application of molecular imaging techniques such as positron emission tomography and single photon emission computed tomography in recent years has begun to provide insight into the molecular mechanisms by which chronic stress confers risk for these disorders. The present paper provides a comprehensive review and synthesis of all positron emission tomography and single photon emission computed tomography imaging publications focused on the examination of molecular targets in individuals with major depressive disorder, posttraumatic stress disorder, or bipolar disorder to date. Critical discussion of discrepant findings and broad strengths and weaknesses of the current body of literature is provided. Recommended future directions for the field of molecular imaging to further elucidate the neurobiological substrates of chronic stress-related disorders are also discussed. This article is part of the inaugural issue for the journal focused on various aspects of chronic stress. |
| first_indexed | 2024-12-22T05:48:24Z |
| format | Article |
| id | doaj.art-ec9f32f1eb2c4e819c5c239d8db772f4 |
| institution | Directory Open Access Journal |
| issn | 2470-5470 |
| language | English |
| last_indexed | 2024-12-22T05:48:24Z |
| publishDate | 2017-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Chronic Stress |
| spelling | doaj.art-ec9f32f1eb2c4e819c5c239d8db772f42022-12-21T18:36:57ZengSAGE PublishingChronic Stress2470-54702017-06-01110.1177/2470547017710916Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from Molecular Imaging StudiesMargaret T. Davis0Sophie E. Holmes1Robert H. Pietrzak2Irina Esterlis3Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT, USADepartment of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT, USAUS Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT, USAUS Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT, USAChronic stress accounts for billions of dollars of economic loss annually in the United States alone, and is recognized as a major source of disability and mortality worldwide. Robust evidence suggests that chronic stress plays a significant role in the onset of severe and impairing psychiatric conditions, including major depressive disorder, bipolar disorder, and posttraumatic stress disorder. Application of molecular imaging techniques such as positron emission tomography and single photon emission computed tomography in recent years has begun to provide insight into the molecular mechanisms by which chronic stress confers risk for these disorders. The present paper provides a comprehensive review and synthesis of all positron emission tomography and single photon emission computed tomography imaging publications focused on the examination of molecular targets in individuals with major depressive disorder, posttraumatic stress disorder, or bipolar disorder to date. Critical discussion of discrepant findings and broad strengths and weaknesses of the current body of literature is provided. Recommended future directions for the field of molecular imaging to further elucidate the neurobiological substrates of chronic stress-related disorders are also discussed. This article is part of the inaugural issue for the journal focused on various aspects of chronic stress.https://doi.org/10.1177/2470547017710916 |
| spellingShingle | Margaret T. Davis Sophie E. Holmes Robert H. Pietrzak Irina Esterlis Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from Molecular Imaging Studies Chronic Stress |
| title | Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from
Molecular Imaging Studies |
| title_full | Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from
Molecular Imaging Studies |
| title_fullStr | Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from
Molecular Imaging Studies |
| title_full_unstemmed | Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from
Molecular Imaging Studies |
| title_short | Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from
Molecular Imaging Studies |
| title_sort | neurobiology of chronic stress related psychiatric disorders evidence from molecular imaging studies |
| url | https://doi.org/10.1177/2470547017710916 |
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