The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article
Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribon...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2021-03-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-2181-en.html |
| _version_ | 1818590830912339968 |
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| author | Noorwati Sutandyo |
| author_facet | Noorwati Sutandyo |
| author_sort | Noorwati Sutandyo |
| collection | DOAJ |
| description | Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle wasting in cancer patients. miRNA has a role in affecting protein regulation, associated with different inflammatory and disease pathways. miRNA can also affect cytokines or directly change the regulation of metabolism that lead to cachexia. In this review, we want to focus on the pathophysiology to give a better understanding about the role of miRNA in the development of cancer cachexia. Based on various pathways of miRNA in cancer cachexia, it can be a potential target for therapeutic strategies. Improved knowledge about miRNA can give the opportunity to develop new treatment in the management of cancer cachexia. |
| first_indexed | 2024-12-16T10:02:47Z |
| format | Article |
| id | doaj.art-ec9f3a3d83074c0b9026355593078fce |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-12-16T10:02:47Z |
| publishDate | 2021-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-ec9f3a3d83074c0b9026355593078fce2022-12-21T22:35:44ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722021-03-01122124128The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review ArticleNoorwati Sutandyo0 Hematology and Medical Oncology Division, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle wasting in cancer patients. miRNA has a role in affecting protein regulation, associated with different inflammatory and disease pathways. miRNA can also affect cytokines or directly change the regulation of metabolism that lead to cachexia. In this review, we want to focus on the pathophysiology to give a better understanding about the role of miRNA in the development of cancer cachexia. Based on various pathways of miRNA in cancer cachexia, it can be a potential target for therapeutic strategies. Improved knowledge about miRNA can give the opportunity to develop new treatment in the management of cancer cachexia.http://caspjim.com/article-1-2181-en.htmlmicro rnacancercachexiamuscle wasting |
| spellingShingle | Noorwati Sutandyo The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article Caspian Journal of Internal Medicine micro rna cancer cachexia muscle wasting |
| title | The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article |
| title_full | The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article |
| title_fullStr | The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article |
| title_full_unstemmed | The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article |
| title_short | The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article |
| title_sort | role of microrna in cancer cachexia and muscle wasting a review article |
| topic | micro rna cancer cachexia muscle wasting |
| url | http://caspjim.com/article-1-2181-en.html |
| work_keys_str_mv | AT noorwatisutandyo theroleofmicrornaincancercachexiaandmusclewastingareviewarticle AT noorwatisutandyo roleofmicrornaincancercachexiaandmusclewastingareviewarticle |