Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review
Type 1 and type 2 diabetes mellitus have an impact on the microstructural environment and cognitive functions of the brain due to its microvascular/macrovascular complications. Conventional Magnetic Resonance Imaging (MRI) techniques can allow detection of brain volume reduction in people with diabe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/2/140 |
| _version_ | 1797408538519142400 |
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| author | Abdulmajeed Alotaibi Christopher Tench Rebecca Stevenson Ghadah Felmban Amjad Altokhis Ali Aldhebaib Rob A. Dineen Cris S. Constantinescu |
| author_facet | Abdulmajeed Alotaibi Christopher Tench Rebecca Stevenson Ghadah Felmban Amjad Altokhis Ali Aldhebaib Rob A. Dineen Cris S. Constantinescu |
| author_sort | Abdulmajeed Alotaibi |
| collection | DOAJ |
| description | Type 1 and type 2 diabetes mellitus have an impact on the microstructural environment and cognitive functions of the brain due to its microvascular/macrovascular complications. Conventional Magnetic Resonance Imaging (MRI) techniques can allow detection of brain volume reduction in people with diabetes. However, conventional MRI is insufficiently sensitive to quantify microstructural changes. Diffusion Tensor Imaging (DTI) has been used as a sensitive MRI-based technique for quantifying and assessing brain microstructural abnormalities in patients with diabetes. This systematic review aims to summarise the original research literature using DTI to quantify microstructural alterations in diabetes and the relation of such changes to cognitive status and metabolic profile. A total of thirty-eight published studies that demonstrate the impact of diabetes mellitus on brain microstructure using DTI are included, and these demonstrate that both type 1 diabetes mellitus and type 2 diabetes mellitus may affect cognitive abilities due to the alterations in brain microstructures. |
| first_indexed | 2024-03-09T04:00:58Z |
| format | Article |
| id | doaj.art-eca4b575a6734b229bd8c04aa217b643 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T04:00:58Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-eca4b575a6734b229bd8c04aa217b6432023-12-03T14:14:26ZengMDPI AGBrain Sciences2076-34252021-01-0111214010.3390/brainsci11020140Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic ReviewAbdulmajeed Alotaibi0Christopher Tench1Rebecca Stevenson2Ghadah Felmban3Amjad Altokhis4Ali Aldhebaib5Rob A. Dineen6Cris S. Constantinescu7Division of Clinical Neuroscience, Nottingham University Hospitals NHS Trust, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UKDivision of Clinical Neuroscience, Nottingham University Hospitals NHS Trust, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UKDivision of Clinical Neuroscience, Nottingham University Hospitals NHS Trust, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UKDivision of Clinical Neuroscience, Nottingham University Hospitals NHS Trust, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UKDivision of Clinical Neuroscience, Nottingham University Hospitals NHS Trust, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UKSchool of Applied Medical Sciences, King Saud bin Abdul-Aziz University for Health Sciences, Riyadh 14611, Saudi ArabiaDivision of Clinical Neuroscience, Nottingham University Hospitals NHS Trust, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UKDivision of Clinical Neuroscience, Nottingham University Hospitals NHS Trust, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UKType 1 and type 2 diabetes mellitus have an impact on the microstructural environment and cognitive functions of the brain due to its microvascular/macrovascular complications. Conventional Magnetic Resonance Imaging (MRI) techniques can allow detection of brain volume reduction in people with diabetes. However, conventional MRI is insufficiently sensitive to quantify microstructural changes. Diffusion Tensor Imaging (DTI) has been used as a sensitive MRI-based technique for quantifying and assessing brain microstructural abnormalities in patients with diabetes. This systematic review aims to summarise the original research literature using DTI to quantify microstructural alterations in diabetes and the relation of such changes to cognitive status and metabolic profile. A total of thirty-eight published studies that demonstrate the impact of diabetes mellitus on brain microstructure using DTI are included, and these demonstrate that both type 1 diabetes mellitus and type 2 diabetes mellitus may affect cognitive abilities due to the alterations in brain microstructures.https://www.mdpi.com/2076-3425/11/2/140diabetes mellitustype 1 diabetestype 2 diabetesdiffusion imagingDiffusion Tensor Imaging (DTI)microstructural abnormalities |
| spellingShingle | Abdulmajeed Alotaibi Christopher Tench Rebecca Stevenson Ghadah Felmban Amjad Altokhis Ali Aldhebaib Rob A. Dineen Cris S. Constantinescu Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review Brain Sciences diabetes mellitus type 1 diabetes type 2 diabetes diffusion imaging Diffusion Tensor Imaging (DTI) microstructural abnormalities |
| title | Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review |
| title_full | Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review |
| title_fullStr | Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review |
| title_full_unstemmed | Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review |
| title_short | Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review |
| title_sort | investigating brain microstructural alterations in type 1 and type 2 diabetes using diffusion tensor imaging a systematic review |
| topic | diabetes mellitus type 1 diabetes type 2 diabetes diffusion imaging Diffusion Tensor Imaging (DTI) microstructural abnormalities |
| url | https://www.mdpi.com/2076-3425/11/2/140 |
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