Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice
Ishophloroglucin A (IPA), a component of <i>Ishige okamurae</i> (IO), was previously evaluated to standardize the antidiabetic potency of IO. However, the potential of IPA as a functional food for diabetes prevention has not yet been evaluated. Here, we investigated if 1.35 mg/kg IPA, wh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/11/608 |
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| author | Hye-Won Yang Myeongjoo Son Junwon Choi Seyeon Oh You-Jin Jeon Kyunghee Byun BoMi Ryu |
| author_facet | Hye-Won Yang Myeongjoo Son Junwon Choi Seyeon Oh You-Jin Jeon Kyunghee Byun BoMi Ryu |
| author_sort | Hye-Won Yang |
| collection | DOAJ |
| description | Ishophloroglucin A (IPA), a component of <i>Ishige okamurae</i> (IO), was previously evaluated to standardize the antidiabetic potency of IO. However, the potential of IPA as a functional food for diabetes prevention has not yet been evaluated. Here, we investigated if 1.35 mg/kg IPA, which is the equivalent content of IPA in 75 mg/kg IO, improved glucose homeostasis in high-fat diet (HFD)-induced diabetes after 12 weeks of treatment. IPA significantly ameliorated glucose intolerance, reducing fasting glucose levels as well as 2 h glucose levels in HFD mice. In addition, IPA exerted a protective effect on the pancreatic function in HFD mice via pancreatic β-cells and C-peptide. The level of glucose transporter 4 (GLUT4) in the muscles of HFD mice was stimulated by IPA intake. Our results suggested that IPA, which is a component of IO, can improve glucose homeostasis via GLUT4 in the muscles of HFD mice. IO may be used as a functional food for the prevention of diabetes. |
| first_indexed | 2024-04-14T01:20:09Z |
| format | Article |
| id | doaj.art-eca554008c88488ca10d39ad0e457178 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:20:09Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-eca554008c88488ca10d39ad0e4571782022-12-22T02:20:40ZengMDPI AGMarine Drugs1660-33972019-10-01171160810.3390/md17110608md17110608Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed MiceHye-Won Yang0Myeongjoo Son1Junwon Choi2Seyeon Oh3You-Jin Jeon4Kyunghee Byun5BoMi Ryu6Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, 1 Ara 1-dong, Jejudaehak-ro, Jeju 63243, KoreaDepartment of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon 21936, KoreaDepartment of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon 21936, KoreaFunctional Cellular Networks Laboratory, College of Medicine, Department of Medicine, Graduate School and Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, KoreaDepartment of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, 1 Ara 1-dong, Jejudaehak-ro, Jeju 63243, KoreaDepartment of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon 21936, KoreaDepartment of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, 1 Ara 1-dong, Jejudaehak-ro, Jeju 63243, KoreaIshophloroglucin A (IPA), a component of <i>Ishige okamurae</i> (IO), was previously evaluated to standardize the antidiabetic potency of IO. However, the potential of IPA as a functional food for diabetes prevention has not yet been evaluated. Here, we investigated if 1.35 mg/kg IPA, which is the equivalent content of IPA in 75 mg/kg IO, improved glucose homeostasis in high-fat diet (HFD)-induced diabetes after 12 weeks of treatment. IPA significantly ameliorated glucose intolerance, reducing fasting glucose levels as well as 2 h glucose levels in HFD mice. In addition, IPA exerted a protective effect on the pancreatic function in HFD mice via pancreatic β-cells and C-peptide. The level of glucose transporter 4 (GLUT4) in the muscles of HFD mice was stimulated by IPA intake. Our results suggested that IPA, which is a component of IO, can improve glucose homeostasis via GLUT4 in the muscles of HFD mice. IO may be used as a functional food for the prevention of diabetes.https://www.mdpi.com/1660-3397/17/11/608functional fooddiabetes<i>ishige okamurae</i>ishophloroglucin a |
| spellingShingle | Hye-Won Yang Myeongjoo Son Junwon Choi Seyeon Oh You-Jin Jeon Kyunghee Byun BoMi Ryu Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice Marine Drugs functional food diabetes <i>ishige okamurae</i> ishophloroglucin a |
| title | Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice |
| title_full | Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice |
| title_fullStr | Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice |
| title_full_unstemmed | Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice |
| title_short | Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice |
| title_sort | effect of ishophloroglucin a a component of i ishige okamurae i on glucose homeostasis in the pancreas and muscle of high fat diet fed mice |
| topic | functional food diabetes <i>ishige okamurae</i> ishophloroglucin a |
| url | https://www.mdpi.com/1660-3397/17/11/608 |
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