YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

The ubiquitin ligase TRAF6 is a key regulator of canonical IκB kinase (IKK)/NF-κB signaling in response to interleukin-1 (IL-1) stimulation. Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interactor of TRAF6 in human cells. YOD1 binds to the C-terminal TRAF homology domain o...

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Bibliographic Details
Main Authors: Gisela Schimmack, Kenji Schorpp, Kerstin Kutzner, Torben Gehring, Jara Kerstin Brenke, Kamyar Hadian, Daniel Krappmann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
signal transduction
interleukin-1
NF-kappaB
ubiquitin
Online Access:https://elifesciences.org/articles/22416

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